Department of Chemistry, 2036 Main Mall, University of British Columbia, Vancouver, B.C., Canada, V6T 1Z1.
J Org Chem. 2010 Dec 17;75(24):8585-90. doi: 10.1021/jo102036n. Epub 2010 Nov 18.
Electron-deficient acyclic enamine derivatives react with electron-rich 1-arylalkynes using cationic gold(I) species as catalysts in an intramolecular process to form annulated 1-amido-substituted indene derivatives as the major products. Yields for this process range between 21% and 98%. In some cases, a two-step process that includes a subsequent alkene isomerization is needed.
缺电子的非环烯胺衍生物在阳离子金（I）物种的催化作用下与富电子的 1-芳基炔反应，在分子内过程中形成稠合的 1-酰胺取代茚衍生物作为主要产物。该反应的产率在 21%至 98%之间。在某些情况下，需要包括随后的烯烃异构化的两步过程。
