Department of Chemistry, 2036 Main Mall, University of British Columbia, Vancouver, BC, Canada V6T 1Z1.
J Org Chem. 2009 Sep 18;74(18):6929-35. doi: 10.1021/jo901512m.
Cyclic enamine derivatives (enesulfonamides and enamides) tethered to an 1-arylalkynyl fragment undergo a platinum(II)-catalyzed tandem alkyne addition/Friedel-Crafts ring closure to form nitrogen-containing polycyclic structures. Regioselectivity in the initial addition of the enesulfonamide or enamide nucleophile to the platinum(II)-alkyne complex is important. Electron-rich arenes and heterocycles led to the formation of products resulting from an initial 6-endo cyclization. Twenty-three examples of this process are presented.
含 1-芳基炔基片段的环烯胺衍生物（烯磺酰胺和烯酰胺）经历铂（II）催化的串联炔加成/Friedel-Crafts 环化反应，形成含氮多环结构。在烯磺酰胺或烯酰胺亲核试剂与铂（II）-炔络合物的初始加成中，区域选择性很重要。富电子芳环和杂环导致形成初始 6-endo 环化反应生成的产物。本文提供了 23 个这种过程的实例。
