RANKL/RANK 系统的生理学和病理生理学。

Physiology and pathophysiology of the RANKL/RANK system.

机构信息

Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria.

出版信息

Biol Chem. 2010 Dec;391(12):1365-70. doi: 10.1515/BC.2010.149.

DOI:10.1515/BC.2010.149

Abstract

The TNF family molecule RANKL and its receptor RANK are key regulators of bone remodeling, lymph node formation, and mammary gland development during pregnancy. RANKL and RANK are also expressed in the central nervous systems (CNS). However, the functional relevance of RANKL/RANK in the brain was entirely unknown. Recently, our group reported that the RANKL/RANK signaling pathway has an essential role in the central regulation of body temperature via the prostaglandin axis. This review discusses novel aspects of the RANKL/RANK system as key regulators of fever and female basal body temperature in the CNS.

摘要

TNF 家族分子 RANKL 和其受体 RANK 是骨骼重塑、妊娠期间淋巴结形成和乳腺发育的关键调节剂。RANKL 和 RANK 也在中枢神经系统（CNS）中表达。然而，RANKL/RANK 在大脑中的功能相关性完全未知。最近，我们的研究小组报道，RANKL/RANK 信号通路通过前列腺素轴在体温的中枢调节中发挥重要作用。本综述讨论了 RANKL/RANK 系统作为 CNS 中发热和女性基础体温关键调节剂的新方面。