Balci Osman, Mahmoud Alaa S, Acar Ali, Colakoglu Mehmet C
Department of Obstetrics and Gynecology, Meram Medicine Faculty, Selcuk University, Konya, Turkey.
J Matern Fetal Neonatal Med. 2011 Sep;24(9):1084-7. doi: 10.3109/14767058.2010.531798. Epub 2010 Nov 19.
To compare the efficacy and complications of intravaginal misoprostol application before starting oxytocin infusion with oxytocin infusion alone for labor induction in term primigravidae pregnancies with low-Bishop score.
This randomized study included 101 primigravidae women with singleton pregnancies >38 weeks and a Bishop score of <6. Group 1 (50 patients) received a 50-μg dose of intravaginal misoprostol, with an oxytocin infusion started 3 h later. Group 2 (51 patients) received only an oxytocin infusion for labor induction. The time from induction to delivery, the route of delivery and complications were analyzed.
The mean time from induction to delivery was 10.4 ± 2.1 h in Group 1 and 13.7 ± 3.4 in Group 2 (p < 0.001). The rates of vaginal delivery, Apgar scores at 1st and 5th min, placental abruption, and postpartum hemorrhage were similar between the two groups.
Intravaginal application of 50-μg misoprostol before starting oxytocin infusion is a more effective method of labor induction than oxytocin infusion alone in term primigravidae pregnant women with low-Bishop scores.
比较在低 Bishop 评分的足月初产妇中，在开始静脉滴注缩宫素前阴道内应用米索前列醇与单纯静脉滴注缩宫素进行引产的疗效及并发症。
这项随机研究纳入了 101 名单胎妊娠大于 38 周且 Bishop 评分小于 6 的初产妇。第 1 组（50 例患者）接受 50μg 阴道内米索前列醇，3 小时后开始静脉滴注缩宫素。第 2 组（51 例患者）仅接受静脉滴注缩宫素引产。分析了引产至分娩的时间、分娩方式及并发症。
第 1 组引产至分娩的平均时间为 10.4±2.1 小时，第 2 组为 13.7±3.4 小时（p<0.001）。两组的阴道分娩率、第 1 分钟和第 5 分钟的 Apgar 评分、胎盘早剥及产后出血发生率相似。
在低 Bishop 评分的足月初产妇中，在开始静脉滴注缩宫素前阴道内应用 50μg 米索前列醇比单纯静脉滴注缩宫素是一种更有效的引产方法。
