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What is the right dose for children?儿童的正确剂量是多少？
Br J Clin Pharmacol. 2010 Oct;70(4):597-603. doi: 10.1111/j.1365-2125.2009.03591.x.
2
Calculation of drug dosage and body surface area of children.儿童药物剂量及体表面积的计算。
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Dose rationale for gabapentin and tramadol in pediatric patients with chronic pain.加巴喷丁和曲马多用于治疗慢性疼痛儿科患者的剂量合理性。
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本文引用的文献

1
A model-based approach to dose selection in early pediatric development.基于模型的早期儿科开发中的剂量选择方法。
Clin Pharmacol Ther. 2010 Mar;87(3):294-302. doi: 10.1038/clpt.2009.234. Epub 2010 Jan 27.
2
Proposals for model-based paediatric medicinal development within the current European Union regulatory framework.现行欧盟监管框架下基于模型的儿科药物开发建议。
Br J Clin Pharmacol. 2009 Oct;68(4):493-501. doi: 10.1111/j.1365-2125.2009.03484.x.
3
Morphine glucuronidation in preterm neonates, infants and children younger than 3 years.早产儿、婴儿和 3 岁以下儿童的吗啡葡萄糖醛酸苷化。
Clin Pharmacokinet. 2009;48(6):371-85. doi: 10.2165/00003088-200948060-00003.
4
To scale or not to scale: the principles of dose extrapolation.是否需要进行剂量外推：剂量外推的原则。
Br J Pharmacol. 2009 Jul;157(6):907-21. doi: 10.1111/j.1476-5381.2009.00267.x. Epub 2009 Jun 5.
5
Optimizing pediatric dosing: a developmental pharmacologic approach.优化儿科用药剂量：一种发育药理学方法。
Pharmacotherapy. 2009 Jun;29(6):680-90. doi: 10.1592/phco.29.6.680.
6
Population pharmacokinetics of valsartan in pediatrics.缬沙坦在儿科人群中的群体药代动力学。
Drug Metab Pharmacokinet. 2009;24(2):145-52. doi: 10.2133/dmpk.24.145.
7
A framework for assessing inter-individual variability in pharmacokinetics using virtual human populations and integrating general knowledge of physical chemistry, biology, anatomy, physiology and genetics: A tale of 'bottom-up' vs 'top-down' recognition of covariates.一种使用虚拟人群评估药代动力学个体间变异性并整合物理化学、生物学、解剖学、生理学和遗传学常识的框架：“自下而上”与“自上而下”识别协变量的故事。
Drug Metab Pharmacokinet. 2009;24(1):53-75. doi: 10.2133/dmpk.24.53.
8
Population pharmacokinetics of levetiracetam and dosing recommendation in children with epilepsy.左乙拉西坦的群体药代动力学及癫痫患儿的给药建议
Epilepsia. 2009 May;50(5):1150-7. doi: 10.1111/j.1528-1167.2008.01974.x. Epub 2009 Jan 19.
9
Tailor-made drug treatment for children: creation of an infrastructure for data-sharing and population PK-PD modeling.儿童定制药物治疗：创建数据共享和群体药代动力学-药效学建模的基础设施
Drug Discov Today. 2009 Mar;14(5-6):316-20. doi: 10.1016/j.drudis.2008.11.004. Epub 2008 Dec 26.
10
Population pharmacokinetics of oral diclofenac for acute pain in children.口服双氯芬酸治疗儿童急性疼痛的群体药代动力学
Br J Clin Pharmacol. 2008 Dec;66(6):846-53. doi: 10.1111/j.1365-2125.2008.03289.x.

What is the right dose for children?

作者信息

Cella Massimo, Knibbe Catherijne, Danhof Meindert, Della Pasqua Oscar

机构信息

Leiden/Amsterdam Center for Drug Research, Leiden University, The Netherlands.

出版信息

Br J Clin Pharmacol. 2010 Oct;70(4):597-603. doi: 10.1111/j.1365-2125.2009.03591.x.

DOI:10.1111/j.1365-2125.2009.03591.x
PMID:21087295
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2950994/
Abstract
摘要