Department of Obstetrics and Gynecology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, Japan.
Am J Reprod Immunol. 2011 May;65(5):449-59. doi: 10.1111/j.1600-0897.2010.00928.x. Epub 2010 Nov 19.
Chemokines are a group of small cytokines that have an ability to induce leukocyte migration. Chemokines exert their functions by binding and activating specific G protein-coupled receptors. Studies have unveiled pleiotropic bioactivities of chemokines in various phenomena ranging from immunomodulation, embryogenesis, and homeostasis to pathogenesis. In the mammalian reproductive system, chemokines unexceptionally serve in multimodal events that are closely associated with establishment, maintenance, and deterioration of fecundity. The aim of this review is to update the knowledge on chemokines in male and female genital organs, with a focus on their potential pathophysiological roles in human reproduction.
趋化因子是一组能够诱导白细胞迁移的小细胞因子。趋化因子通过与特定的 G 蛋白偶联受体结合和激活来发挥作用。研究揭示了趋化因子在从免疫调节、胚胎发生和体内平衡到发病机制的各种现象中的多种生物活性。在哺乳动物生殖系统中，趋化因子在与生育能力的建立、维持和恶化密切相关的多种事件中发挥作用。本综述的目的是更新关于男性和女性生殖器官中趋化因子的知识，重点关注它们在人类生殖中的潜在病理生理作用。
