Amano Namiko, Kitaya Kotaro, Taguchi Sagiri, Funabiki Miyako, Tada Yoshihiro, Hayashi Terumi, Nakamura Yoshitaka
IVF Center, Oak Clinic, Osaka 557-0045, Japan.
Biomed Rep. 2014 May;2(3):429-431. doi: 10.3892/br.2014.251. Epub 2014 Mar 12.
The aim of this study was to compare the branched-chain amino acid (BCAA) and tyrosine concentration in the follicular fluid of infertile women with and without ovarian hyperstimulation syndrome (OHSS) in an fertilization program combined with controlled ovarian stimulation. Follicular fluid was aspirated during oocyte retrieval from 20 infertile patients who developed moderate-to-severe OHSS and 20 age- and body mass index-matched normoresponders. BCAA and tyrosine concentration were measured using enzymatic methods. The follicular fluid BCAA concentration was similar between the two groups (P=0.55), whereas tyrosine concentration was significantly lower in the OHSS compared to that in the normoresponder group (P=0.027) and the BCAA/tyrosine ratio was significantly higher in the OHSS compared to that in the normoresponder group (P=0.034). These results suggest an association between low follicular fluid tyrosine concentration and OHSS. Dopamine receptor agonists may be used as potential anti-OHSS medicines and tyrosine, as a dopamine precursor, may play a role against the development of OHSS.
本研究旨在比较在一项结合控制性卵巢刺激的受精程序中，患有和未患有卵巢过度刺激综合征（OHSS）的不孕女性卵泡液中支链氨基酸（BCAA）和酪氨酸的浓度。在取卵过程中，从20例发生中度至重度OHSS的不孕患者以及20例年龄和体重指数匹配的正常反应者中抽吸卵泡液。使用酶法测量BCAA和酪氨酸浓度。两组之间卵泡液BCAA浓度相似（P = 0.55），而OHSS组的酪氨酸浓度显著低于正常反应者组（P = 0.027），且OHSS组的BCAA/酪氨酸比值显著高于正常反应者组（P = 0.034）。这些结果表明卵泡液酪氨酸浓度低与OHSS之间存在关联。多巴胺受体激动剂可能用作潜在的抗OHSS药物，而酪氨酸作为多巴胺前体，可能在对抗OHSS的发展中发挥作用。
