Walker V, Mills G A
Department of Clinical Biochemistry, Southampton University, UK.
Biol Neonate. 1990;57(3-4):155-66. doi: 10.1159/000243186.
Random urine samples collected weekly from 22 infants of 25-32 weeks of gestation were analyzed by capillary gas chromatography-mass spectrometry to define the normal organic acid profile. Increased excretion of phenolic acid derivatives of phenylalanine and tyrosine was found in 21 samples from 13 babies during established parenteral nutrition. Compared with 53 samples collected during milk feeding, phenyllactic acid, 4-hydroxy-3-methoxyphenyllactic acid, and N-acetyltyrosine were excreted significantly more often and 4-hydroxyphenyllactic and 4-hydroxyphenylpyruvic acids at significantly higher concentrations. The mean daily intake of phenylalanine (197 mg/kg) was significantly higher and that of tyrosine (22 mg/kg) significantly lower during parenteral nutrition. Three cyclohexanediol isomers were identified which might have derived from phenylalanine or one of its metabolites.
每周从22名孕周为25 - 32周的婴儿收集随机尿液样本，通过毛细管气相色谱 - 质谱分析法进行分析，以确定正常的有机酸谱。在13名婴儿接受肠外营养期间采集的21份样本中，发现苯丙氨酸和酪氨酸的酚酸衍生物排泄增加。与母乳喂养期间采集的53份样本相比，苯乳酸、4 - 羟基 - 3 - 甲氧基苯乳酸和N - 乙酰酪氨酸排泄频率显著更高，4 - 羟基苯乳酸和4 - 羟基苯丙酮酸浓度显著更高。肠外营养期间苯丙氨酸的平均每日摄入量（197毫克/千克）显著更高，酪氨酸的平均每日摄入量（22毫克/千克）显著更低。鉴定出三种环己二醇异构体，它们可能源自苯丙氨酸或其一种代谢物。
