Dangardt Frida, Volkmann Reinhard, Chen Yun, Osika Walter, Mårild Staffan, Friberg Peter
Department of Molecular and Clinical Medicine, Clinical Physiology Department of Paediatrics, Sahlgrenska Academy and University Hospital, Göteborg, Sweden.
Clin Physiol Funct Imaging. 2011 Mar;31(2):108-13. doi: 10.1111/j.1475-097X.2010.00985.x. Epub 2010 Nov 18.
Obese children present with various cardiovascular risk factors affecting their future health. In adults, cardiac autonomic function is a major risk factor, predicting cardiovascular morbidity and mortality. We hypothesized that obese children and adolescents had a lower cardiac vagal activity than lean subjects. We measured cardiac spontaneous baroreflex sensitivity (BRS), reflecting the dynamic regulation of cardiac vagal function, in large groups of obese and lean young individuals.
Cardiac BRS, using the sequence approach, was assessed in 120 obese (59 girls), 43 overweight (23 girls) and 148 lean subjects (78 girls). Obese subjects showed a decreased BRS compared to both overweight and lean subjects [16±7 versus 21±9 (P<0·01) and 22±10 ms per mmHg (P<0·0001), respectively]. The differences remained after correcting for age, gender and pubertal status.
Children with obesity had low vagal activity at rest, and there was no gender difference.
肥胖儿童存在多种影响其未来健康的心血管危险因素。在成年人中，心脏自主神经功能是一个主要危险因素，可预测心血管疾病的发病率和死亡率。我们假设肥胖儿童和青少年的心脏迷走神经活动低于瘦人。我们在大量肥胖和瘦的年轻个体中测量了反映心脏迷走神经功能动态调节的心脏自发压力反射敏感性（BRS）。
采用序列法对120名肥胖者（59名女孩）、43名超重者（23名女孩）和148名瘦人（78名女孩）进行了心脏BRS评估。与超重和瘦人相比，肥胖者的BRS降低[分别为16±7与21±9（P<0·01）和22±10毫秒/毫米汞柱（P<0·0001）]。在校正年龄、性别和青春期状态后，差异仍然存在。
肥胖儿童静息时迷走神经活动较低，且无性别差异。
