刺激强度对去甲肾上腺素释放的α-肾上腺素能受体介导的反馈控制的影响。
The effect of stimulus intensity on alpha-adrenoceptor-mediated feedback control of noradrenaline release.
作者信息
Harper B, Hughes I E
出版信息
Br J Pharmacol. 1978 Aug;63(4):689-91. doi: 10.1111/j.1476-5381.1978.tb17284.x.
Abstract
1 Mouse vas deferns stimulated transmurally (2.5 Hz, 2-32 V, 40-620 mA, FOR 45 s) responded with a twitch and a secondary contraction. Both responses were abolished by cinchocaine and were voltage-dependent. 2 In tissues previously incubated with (3H)-(--)-noradrenaline, stimulation also produced an increase in tritium overflow from the tissue. Phentolamine increased tritium overflow by 19% at high stimulus intensities (30 V, 600 mA) and by 130% at low stimulus intensities (11 V, 200 mA). 3 It is concluded that alpha-adrenoceptor-mediated feedback control of noradrenaline release is more marked at low stimulus intensities and that this is compatible with a role for calcium ions in this control mechanism.
摘要
- 经壁刺激（2.5赫兹，2 - 32伏，40 - 620毫安，持续45秒）的小鼠输精管会产生一次抽搐和一次继发性收缩。这两种反应均被辛可卡因消除，且呈电压依赖性。2. 在先前用（3H）-（-）-去甲肾上腺素孵育过的组织中，刺激也会使组织中的氚溢出增加。在高刺激强度（30伏，600毫安）下，酚妥拉明使氚溢出增加19%，在低刺激强度（11伏，200毫安）下增加130%。3. 得出的结论是，α - 肾上腺素能受体介导的去甲肾上腺素释放反馈控制在低刺激强度下更为明显，且这与钙离子在该控制机制中的作用相符。
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The effect of stimulus intensity on alpha-adrenoceptor-mediated feedback control of noradrenaline release.刺激强度对去甲肾上腺素释放的α-肾上腺素能受体介导的反馈控制的影响。
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引用本文的文献
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Site(s) and ionic basis of alpha-autoinhibition and facilitation of "3H'noradrenaline secretion in guinea-pig vas deferens.豚鼠输精管中α-自身抑制及“3H”去甲肾上腺素分泌促进作用的位点及离子基础。
J Physiol. 1981 Mar;312:297-334. doi: 10.1113/jphysiol.1981.sp013630.
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Single pulse stimulation of guinea-pig vas deferens and the presynaptic receptor hypothesis.豚鼠输精管的单脉冲刺激与突触前受体假说
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本文引用的文献
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Br J Pharmacol Chemother. 1966 Oct;28(1):105-27. doi: 10.1111/j.1476-5381.1966.tb01878.x.
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Electrical field-stimulated release of norepinephrine-H3 from rat atrium: effects of ions and drugs.电场刺激大鼠心房中去甲肾上腺素 - H3 的释放：离子和药物的作用。
J Pharmacol Exp Ther. 1969 Oct;169(2):229-36.
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Drug-induced changes in the release of ( 3 H)-noradrenaline from field stimulated rat iris.药物诱导的大鼠虹膜经场刺激后（3H）-去甲肾上腺素释放的变化
Br J Pharmacol. 1971 Sep;43(1):97-106. doi: 10.1111/j.1476-5381.1971.tb07160.x.
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Physiol Rev. 1977 Oct;57(4):659-728. doi: 10.1152/physrev.1977.57.4.659.
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