Charité-Universitätsmedizin Berlin, Department of Dermatology and Allergology, Center of Experimental and Cutaneous Physiology (CCP), Berlin, Germany.
J Control Release. 2011 Feb 28;150(1):45-8. doi: 10.1016/j.jconrel.2010.11.015. Epub 2010 Nov 16.
Hair follicles represent interesting target sites for topically applied substances such as topical vaccinations or agents used in the field of regenerative medicine. In recent years, it could be shown that particles penetrate very effectively into the hair follicles. In the present study, the influence of particle size on the follicular penetration depths was examined. The penetration depths of two different types of particles sized 122 to 1000 nm were determined in vitro on porcine skin. The results revealed that the particles of medium size (643 and 646 nm, respectively) penetrated deeper into the porcine hair follicles than smaller or larger particles. It was concluded that by varying the particle size, different sites within the porcine hair follicle can be targeted selectively. For the human terminal hair follicle, the situation can be expected to be similar due to a similar size ratio of the hair follicles.
毛囊是外用物质（如局部疫苗接种或再生医学领域中使用的药物）的有趣作用靶点。近年来，已经证实颗粒能够非常有效地穿透毛囊。在本研究中，研究人员考察了颗粒大小对毛囊穿透深度的影响。在体外实验中，研究人员分别用两种不同粒径（122nm 到 1000nm）的颗粒处理猪皮，确定了颗粒的穿透深度。结果表明，中等粒径（分别为 643nm 和 646nm）的颗粒比更小或更大的颗粒穿透猪毛囊更深。研究人员得出结论，通过改变颗粒大小，可以有选择地靶向猪毛囊的不同部位。由于人类终毛毛囊的大小比例相似，因此可以预期类似的情况。
