Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, The Netherlands.
Curr Opin Immunol. 2010 Dec;22(6):821-6. doi: 10.1016/j.coi.2010.10.013. Epub 2010 Nov 17.
A long standing paradigm is that antigen-specific Th2 cells and their cytokines such as IL-4, IL-5, and IL-13 orchestrate the characteristic features of atopic allergy. The discovery of a role for IL-17-producing (Th17) and IL-22-producing (Th22) T helper cells in inflammatory diseases has added an additional layer of complexity to the understanding of the pathogenesis of allergic diseases. Here we re-evaluate the role of T helper cells, with special focus on the Th17 and Th22 subsets in allergic asthma and atopic dermatitis. Whereas sparse data point to a protective role of the increasing amounts of Th22 cells that are found in chronic stages of both allergies, the data on Th17 cells paint different pictures for the contribution of Th17 cells during subsequent stages of these two forms of allergy.
长期以来，一个范式是抗原特异性 Th2 细胞及其细胞因子（如 IL-4、IL-5 和 IL-13）协调特应性过敏的特征。IL-17 产生（Th17）和 IL-22 产生（Th22）辅助性 T 细胞在炎症性疾病中的作用的发现，为理解过敏性疾病的发病机制增加了一个额外的复杂性。在这里，我们重新评估辅助性 T 细胞的作用，特别关注 Th17 和 Th22 亚群在过敏性哮喘和特应性皮炎中的作用。虽然数据表明，在过敏的慢性阶段发现的 Th22 细胞数量增加可能具有保护作用，但关于 Th17 细胞的数据为这两种过敏形式的后续阶段 Th17 细胞的作用描绘了不同的画面。
