炎症性皮肤病中的白细胞介素-17
Interleukin-17 in inflammatory skin disorders.
作者信息
van Beelen Astrid J, Teunissen Marcel B M, Kapsenberg Martien L, de Jong Esther C
机构信息
Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
出版信息
Curr Opin Allergy Clin Immunol. 2007 Oct;7(5):374-81. doi: 10.1097/ACI.0b013e3282ef869e.
PURPOSE OF REVIEW
Recently, a novel and unique subset of interleukin (IL)-17-producing CD4+ T helper (Th17) cells, distinct from Th1 and Th2 cells, was discovered. The question is addressed as to what extent inflammatory skin diseases are associated with the actions of this newly discovered Th17 cell subset.
RECENT FINDINGS
Th17 cells are involved in protection against bacterial pathogens. In addition, it is now clear that Th17 cells may also be crucial in the pathogenesis of various chronic inflammatory diseases that were formerly categorized as Th1-mediated disorders.
SUMMARY
In this review, we summarize the current knowledge of IL-17 and Th17 cells and discuss the possible role of IL-17 in the pathology of psoriasis, contact hypersensitivity and atopic dermatitis. Whereas IL-17 may play an important role in the pathogenesis of psoriasis and contact hypersensitivity, its role in atopic dermatitis is still unclear.
综述目的
最近，发现了一种新型且独特的产生白细胞介素（IL）-17的CD4 +辅助性T（Th17）细胞亚群，它不同于Th1和Th2细胞。本文探讨了炎症性皮肤病与这个新发现的Th17细胞亚群的作用在多大程度上相关。
最新发现
Th17细胞参与抵御细菌病原体。此外，现在很清楚的是，Th17细胞在各种以前被归类为Th1介导的慢性炎症性疾病的发病机制中也可能起关键作用。
总结
在本综述中，我们总结了目前关于IL-17和Th17细胞的知识，并讨论了IL-17在银屑病、接触性超敏反应和特应性皮炎病理中的可能作用。虽然IL-17可能在银屑病和接触性超敏反应的发病机制中起重要作用，但其在特应性皮炎中的作用仍不清楚。
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