Depersonalization Disorder Unit, Institute of Psychiatry, King's College, London, United Kingdom.
Conscious Cogn. 2011 Mar;20(1):99-108. doi: 10.1016/j.concog.2010.10.018. Epub 2010 Nov 17.
Depersonalization is characterised by a profound disruption of self-awareness mainly characterised by feelings of disembodiment and subjective emotional numbing. It has been proposed that depersonalization is caused by a fronto-limbic (particularly anterior insula) suppressive mechanism--presumably mediated via attention--which manifests subjectively as emotional numbing, and disables the process by which perception and cognition normally become emotionally coloured, giving rise to a subjective feeling of 'unreality'. Our functional neuroimaging and psychophysiological studies support the above model and indicate that, compared with normal and clinical controls, DPD patients show increased prefrontal activation as well as reduced activation in insula/limbic-related areas to aversive, arousing emotional stimuli. Although a putative inhibitory mechanism on emotional processing might account for the emotional numbing and characteristic perceptual detachment, it is likely, as suggested by some studies, that parietal mechanisms underpin feelings of disembodiment and lack of agency feelings.
人格解体的特征是自我意识的深刻中断，主要表现为脱体感和主观情感麻木。有人提出，人格解体是由额-边缘（特别是前脑岛）抑制机制引起的，这种机制可能通过注意力来介导，表现为主观上的情感麻木，并使感知和认知正常变得情绪化的过程失效，从而产生一种主观的“不真实”感。我们的功能神经影像学和心理生理学研究支持上述模型，并表明与正常和临床对照组相比，DPD 患者对厌恶、唤起情绪刺激的前额叶激活增加，而岛叶/边缘相关区域的激活减少。尽管情绪处理的假设抑制机制可能解释了情感麻木和特征性的知觉分离，但正如一些研究表明的那样，躯体感觉缺失和缺乏代理感可能是由顶叶机制引起的。
