Tumour Biology, Northeastern Ontarion Regional Cancer Program, Sudbury Regional Hospital, Sudbury, Ontario, Canada.
Cell Cycle. 2010 Nov 15;9(22):4487-91. doi: 10.4161/cc.9.22.14047.
Genome replication is the most fundamental element of the continuity of life. In eukaryotes, DNA replication is regulated by an elegant network of many different protein factors to ensure the timely and accurate copying of their entire genome once per cell cycle. The replication factors include the maintenance (MCM) proteins, Cdt1, Cdc6, Cdc7, Cdc45, and geminin. All of these proteins are involved in the regulation of DNA replication at the initiation step. Interestingly, recent studies have shown that some of these replication proteins also localize to the centrosome, often throughout the entire cell cycle. These centrosomally localized replication proteins appear to play essential roles in the regulation of centrosome biogenesis, suggesting that genome replication and segregation are regulated interdependently. In this review, we summarize and discuss the inter-dependent regulation played by some of the replication proteins.
基因组复制是生命连续性的最基本要素。在真核生物中，DNA 复制受到许多不同蛋白质因子的精巧网络调控，以确保在每个细胞周期内准确无误地复制其整个基因组。这些复制因子包括维持（MCM）蛋白、Cdt1、Cdc6、Cdc7、Cdc45 和 geminin。所有这些蛋白质都参与了 DNA 复制起始步骤的调控。有趣的是，最近的研究表明，其中一些复制蛋白也定位于中心体，通常在整个细胞周期中都存在。这些定位于中心体的复制蛋白似乎在调控中心体发生中发挥着重要作用，表明基因组复制和分离是相互依赖调节的。在这篇综述中，我们总结和讨论了一些复制蛋白的相互依赖调节。
