Department of Integrative Physiology, University of Colorado, Boulder, CO 80309-0354, USA.
Psychopharmacology (Berl). 2011 Feb;213(2-3):243-64. doi: 10.1007/s00213-010-2089-z. Epub 2010 Nov 19.
Dysfunction of serotonergic systems is thought to play an important role in a number of neurological and psychiatric disorders. Recent studies suggest that there is anatomical and functional diversity among serotonergic systems innervating forebrain systems involved in the control of physiologic and behavioral responses, including the control of emotional states.
Here, we highlight the methods that have been used to investigate the heterogeneity of serotonergic systems and review the evidence for the unique anatomical, hodological, and functional properties of topographically organized subpopulations of serotonergic neurons in the midbrain and pontine raphe complex.
The emerging understanding of the topographically organized synaptic regulation of brainstem serotonergic systems, the topography of the efferent projections of these systems, and their functional properties, should enable identification of novel therapeutic approaches to treatment of neurological and psychiatric conditions that are associated with dysregulation of serotonergic systems.
人们认为，5-羟色胺能系统的功能障碍在许多神经和精神疾病中起着重要作用。最近的研究表明，作用于参与控制生理和行为反应（包括情绪状态控制）的前脑系统的 5-羟色胺能系统在解剖和功能上存在多样性。
在这里，我们重点介绍了用于研究 5-羟色胺能系统异质性的方法，并回顾了中脑和脑桥蓝斑复合体内 5-羟色胺能神经元的拓扑组织亚群的独特解剖、投射和功能特性的证据。
对脑干 5-羟色胺能系统的突触调节的拓扑组织、这些系统的传出投射的拓扑结构及其功能特性的理解不断加深，应该能够确定针对与 5-羟色胺能系统失调相关的神经和精神疾病的新型治疗方法。
