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针刺对啮齿动物神经退行性疾病模型的作用机制：文献综述

The mechanistic effects of acupuncture in rodent neurodegenerative disease models: a literature review.

作者信息

Li Boxuan, Deng Shizhe, Jiang Hailun, Zhu Weiming, Zhuo Bifang, Du Yuzheng, Meng Zhihong

机构信息

National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China.

First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.

出版信息

Front Neurosci. 2024 Mar 4;18:1323555. doi: 10.3389/fnins.2024.1323555. eCollection 2024.

DOI:10.3389/fnins.2024.1323555
PMID:38500484
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10944972/
Abstract

Neurodegenerative diseases refer to a battery of medical conditions that affect the survival and function of neurons in the brain, which are mainly presented with progressive loss of cognitive and/or motor function. Acupuncture showed benign effects in improving neurological deficits, especially on movement and cognitive function impairment. Here, we reviewed the therapeutic mechanisms of acupuncture at the neural circuit level in movement and cognition disorders, summarizing the influence of acupuncture in the dopaminergic system, glutamatergic system, γ-amino butyric acid-ergic (GABAergic) system, serotonergic system, cholinergic system, and glial cells at the circuit and synaptic levels. These findings can provide targets for clinical treatment and perspectives for further studies.

摘要

神经退行性疾病指的是一系列影响大脑神经元存活和功能的医学病症，主要表现为认知和/或运动功能的进行性丧失。针灸在改善神经功能缺损方面显示出良性效果，尤其是对运动和认知功能障碍。在此，我们回顾了针灸在运动和认知障碍的神经回路水平上的治疗机制，总结了针灸在回路和突触水平对多巴胺能系统、谷氨酸能系统、γ-氨基丁酸能（GABA能）系统、5-羟色胺能系统、胆碱能系统和神经胶质细胞的影响。这些发现可为临床治疗提供靶点，并为进一步研究提供方向。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/686f/10944972/11198551c456/fnins-18-1323555-g006.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/686f/10944972/463591ecfc2f/fnins-18-1323555-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/686f/10944972/5bd5a143e116/fnins-18-1323555-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/686f/10944972/a0c8b6af8f58/fnins-18-1323555-g003.jpg
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