Han Mingli, Wu Chengyi
Department of Endocrine Surgery, First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2010 Oct;27(5):1183-6.
Aldehyde dehydrogenase 1 (ALDH1, ALDH1A1 or RALDH1), an enzyme responsible for the oxidation of intracellular aldehydes, was shown to have a function in the early differentiation of stem cells. Its activity shows promising potential as a universal marker for the identification and isolation of normal stem cells and cancer stem cells from multiple sources in a variety of tissue types. Herein, we review the available data reporting the utilization of ALDH1 activity as a means to identify and isolate normal stem cells and cancer stem cells (CSCs), and the potential diagnostic and therapeutic implications, with a special focus on the mammary gland and breast cancer. The research opportunity in this area of interest is emphasized.
醛脱氢酶1（ALDH1、ALDH1A1或RALDH1）是一种负责细胞内醛氧化的酶，已被证明在干细胞的早期分化中发挥作用。其活性作为一种通用标记物，在从多种组织类型的多个来源中鉴定和分离正常干细胞及癌症干细胞方面显示出巨大潜力。在此，我们综述了现有数据，这些数据报道了利用ALDH1活性来鉴定和分离正常干细胞及癌症干细胞（CSCs），以及其潜在的诊断和治疗意义，特别关注乳腺和乳腺癌。强调了这一研究领域的机会。
