Pediatrics. 2006 May;117(5):e989-1004. doi: 10.1542/peds.2006-0219.
This publication presents the 2005 American Heart Association (AHA) guidelines for cardiopulmonary resuscitation (CPR) and emergency cardiovascular care (ECC) of the pediatric patient and the 2005 American Academy of Pediatrics/AHA guidelines for CPR and ECC of the neonate. The guidelines are based on the evidence evaluation from the 2005 International Consensus Conference on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations, hosted by the American Heart Association in Dallas, Texas, January 23-30, 2005. The "2005 AHA Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care" contain recommendations designed to improve survival from sudden cardiac arrest and acute life-threatening cardiopulmonary problems. The evidence evaluation process that was the basis for these guidelines was accomplished in collaboration with the International Liaison Committee on Resuscitation (ILCOR). The ILCOR process is described in more detail in the "International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations." The recommendations in the "2005 AHA Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care" confirm the safety and effectiveness of many approaches, acknowledge that other approaches may not be optimal, and recommend new treatments that have undergone evidence evaluation. These new recommendations do not imply that care involving the use of earlier guidelines is unsafe. In addition, it is important to note that these guidelines will not apply to all rescuers and all victims in all situations. The leader of a resuscitation attempt may need to adapt application of the guidelines to unique circumstances. The following are the major pediatric advanced life support changes in the 2005 guidelines: There is further caution about the use of endotracheal tubes. Laryngeal mask airways are acceptable when used by experienced providers. Cuffed endotracheal tubes may be used in infants (except newborns) and children in in-hospital settings provided that cuff inflation pressure is kept <20 cm H2O. Confirmation of tube placement requires clinical assessment and assessment of exhaled carbon dioxide (CO2); esophageal detector devices may be considered for use in children weighing >20 kg who have a perfusing rhythm. Correct placement must be verified when the tube is inserted, during transport, and whenever the patient is moved. During CPR with an advanced airway in place, rescuers will no longer perform "cycles" of CPR. Instead, the rescuer performing chest compressions will perform them continuously at a rate of 100/minute without pauses for ventilation. The rescuer providing ventilation will deliver 8 to 10 breaths per minute (1 breath approximately every 6-8 seconds). Timing of 1 shock, CPR, and drug administration during pulseless arrest has changed and now is identical to that for advanced cardiac life support. Routine use of high-dose epinephrine is not recommended. Lidocaine is de-emphasized, but it can be used for treatment of ventricular fibrillation/pulseless ventricular tachycardia if amiodarone is not available. Induced hypothermia (32-34 degrees C for 12-24 hours) may be considered if the child remains comatose after resuscitation. Indications for the use of inodilators are mentioned in the postresuscitation section. Termination of resuscitative efforts is discussed. It is noted that intact survival has been reported following prolonged resuscitation and absence of spontaneous circulation despite 2 doses of epinephrine. The following are the major neonatal resuscitation changes in the 2005 guidelines: Supplementary oxygen is recommended whenever positive-pressure ventilation is indicated for resuscitation; free-flow oxygen should be administered to infants who are breathing but have central cyanosis. Although the standard approach to resuscitation is to use 100% oxygen, it is reasonable to begin resuscitation with an oxygen concentration of less than 100% or to start with no supplementary oxygen (ie, start with room air). If the clinician begins resuscitation with room air, it is recommended that supplementary oxygen be available to use if there is no appreciable improvement within 90 seconds after birth. In situations where supplementary oxygen is not readily available, positive-pressure ventilation should be administered with room air. Current recommendations no longer advise routine intrapartum oropharyngeal and nasopharyngeal suctioning for infants born to mothers with meconium staining of amniotic fluid. Endotracheal suctioning for infants who are not vigorous should be performed immediately after birth. A self-inflating bag, a flow-inflating bag, or a T-piece (a valved mechanical device designed to regulate pressure and limit flow) can be used to ventilate a newborn. An increase in heart rate is the primary sign of improved ventilation during resuscitation. Exhaled CO2 detection is the recommended primary technique to confirm correct endotracheal tube placement when a prompt increase in heart rate does not occur after intubation. The recommended intravenous (IV) epinephrine dose is 0.01 to 0.03 mg/kg per dose. Higher IV doses are not recommended, and IV administration is the preferred route. Although access is being obtained, administration of a higher dose (up to 0.1 mg/kg) through the endotracheal tube may be considered. It is possible to identify conditions associated with high mortality and poor outcome in which withholding resuscitative efforts may be considered reasonable, particularly when there has been the opportunity for parental agreement. The following guidelines must be interpreted according to current regional outcomes: When gestation, birth weight, or congenital anomalies are associated with almost certain early death and when unacceptably high morbidity is likely among the rare survivors, resuscitation is not indicated. Examples are provided in the guidelines. In conditions associated with a high rate of survival and acceptable morbidity, resuscitation is nearly always indicated. In conditions associated with uncertain prognosis in which survival is borderline, the morbidity rate is relatively high, and the anticipated burden to the child is high, parental desires concerning initiation of resuscitation should be supported. Infants without signs of life (no heartbeat and no respiratory effort) after 10 minutes of resuscitation show either a high mortality rate or severe neurodevelopmental disability. After 10 minutes of continuous and adequate resuscitative efforts, discontinuation of resuscitation may be justified if there are no signs of life.
本出版物介绍了2005年美国心脏协会(AHA)关于儿科患者心肺复苏(CPR)和紧急心血管护理(ECC)的指南,以及2005年美国儿科学会/AHA关于新生儿CPR和ECC的指南。这些指南基于2005年1月23日至30日在美国德克萨斯州达拉斯市由美国心脏协会主办的“2005年国际心肺复苏和紧急心血管护理科学与治疗建议共识会议”的证据评估。“2005年AHA心肺复苏和紧急心血管护理指南”包含旨在提高心脏骤停和急性危及生命的心肺问题存活率的建议。作为这些指南基础的证据评估过程是与国际复苏联合委员会(ILCOR)合作完成的。ILCOR的过程在“心肺复苏和紧急心血管护理科学与治疗建议国际共识”中有更详细的描述。“2005年AHA心肺复苏和紧急心血管护理指南”中的建议确认了许多方法的安全性和有效性,承认其他方法可能不是最佳的,并推荐了经过证据评估的新治疗方法。这些新建议并不意味着使用早期指南的护理不安全。此外,需要注意的是,这些指南并不适用于所有救援人员和所有情况下的所有受害者。复苏尝试的领导者可能需要根据独特情况调整指南的应用。以下是2005年指南中主要的儿科高级生命支持变化:对气管内导管的使用进一步谨慎。经验丰富的医护人员使用喉罩气道是可以接受的。在医院环境中,婴儿(新生儿除外)和儿童可使用带套囊的气管内导管,前提是套囊充气压力保持<20 cm H2O。确认导管位置需要临床评估和呼出二氧化碳(CO2)评估;对于体重>20 kg且有灌注节律的儿童,可考虑使用食管探测器装置。插入导管时、转运过程中以及患者移动时,必须验证正确的位置。在有高级气道的情况下进行心肺复苏时,救援人员将不再进行心肺复苏“周期”。相反,进行胸外按压的救援人员将以每分钟100次的速率持续进行按压,不进行通气暂停。提供通气的救援人员将每分钟进行8至10次呼吸(大约每6 - 8秒1次呼吸)。无脉性心脏骤停期间1次电击、心肺复苏和药物给药的时机已改变,现在与高级心脏生命支持相同。不建议常规使用大剂量肾上腺素。利多卡因的重要性降低,但如果没有胺碘酮,可用于治疗心室颤动/无脉性室性心动过速。如果儿童复苏后仍昏迷,可考虑诱导低温(32 - 34摄氏度,持续12 - 24小时)。复苏后部分提到了使用血管扩张剂的指征。讨论了复苏努力的终止。需要注意的是,尽管使用了2剂肾上腺素,但仍有报道称在长时间复苏且无自主循环的情况下实现了完整存活。以下是2005年指南中主要的新生儿复苏变化:每当需要进行正压通气进行复苏时,建议补充氧气;对于有呼吸但有中心性发绀的婴儿,应给予自由流动的氧气。尽管复苏的标准方法是使用100%氧气,但以低于100%的氧气浓度开始复苏或不补充氧气(即从室内空气开始)也是合理的。如果临床医生从室内空气开始复苏,建议如果出生后90秒内没有明显改善,应准备好补充氧气以供使用。在补充氧气不易获得的情况下,应使用室内空气进行正压通气。目前的建议不再建议对羊水有胎粪污染的母亲所生的婴儿常规进行产时口咽和鼻咽吸引。对于无活力的婴儿,应在出生后立即进行气管内吸引。可使用自动充气式气囊、气流充气式气囊或T形管(一种用于调节压力和限制流量的带阀机械装置)对新生儿进行通气。心率增加是复苏期间通气改善的主要标志。当插管后心率未迅速增加时,呼出CO2检测是确认气管内导管正确位置的推荐主要技术。推荐的静脉注射(IV)肾上腺素剂量为每剂0.01至0.03 mg/kg。不建议使用更高的静脉剂量,静脉给药是首选途径。尽管正在建立静脉通路,但在无法进行静脉给药时,可考虑通过气管内导管给予更高剂量(高达0.1 mg/kg)。可以识别出与高死亡率和不良结局相关的情况,在这些情况下,特别是在获得父母同意的情况下,考虑放弃复苏努力可能是合理的。必须根据当前区域结果来解释以下指南:当孕周、出生体重或先天性异常几乎肯定会导致早期死亡,且罕见幸存者中可能出现不可接受的高发病率时,不建议进行复苏。指南中提供了示例。在与高存活率和可接受的发病率相关的情况下,几乎总是建议进行复苏。在预后不确定、存活处于临界状态、发病率相对较高且对儿童预期负担较高的情况下,应支持父母关于开始复苏的意愿。复苏10分钟后仍无生命迹象(无心跳和无呼吸努力)的婴儿显示出高死亡率或严重的神经发育残疾。经过10分钟持续且充分的复苏努力后,如果没有生命迹象,停止复苏可能是合理的。