Duskin-Bitan Hadar, Kivity Shaye, Olchovsky David, Schiby Ginette, Ezra David, Mouallem Meir
Department of Medicine A, Sheba Medical Center, Tel Hashomer, Israel.
Isr Med Assoc J. 2010 Oct;12(10):617-21.
Kikuchi-Fujimoto disease is a benign and self-limited disease, first reported in Japan in 1972. The characteristic features of this disorder include lymphadenopathy and fever.
To summarize our experience with Kikuchi disease with regard to clinical manifestations and outcome.
The patients included in the study were those diagnosed with Kikuchi disease during the years 2005-2008 in two departments of internal medicine at Sheba Medical Center.
We identified five patients with Kikuchi disease; four were women and the mean age was 22.6 years. All the patients had cervical lymphadenopathy; three had other sites of lymphadenopathy. Four of the patients had fever higher than 39 degrees C. Two of them had splenomegaly and three reported weight loss. Three of the five patients experienced a relapse of the disease and were treated with steroids or non-steroidal anti-inflammatory agents. The diagnosis was confirmed in all the patients by an excisional biopsy of lymph node.
Kikuchi disease must be considered in every young patient with fever and lymphadenopathy. The disease usually has a benign course.
菊池-藤本病是一种良性自限性疾病，1972年首次在日本报道。该疾病的特征包括淋巴结病和发热。
总结我们在菊池病临床表现及预后方面的经验。
纳入研究的患者为2005年至2008年期间在舍巴医疗中心两个内科诊断为菊池病的患者。
我们确定了5例菊池病患者；4例为女性，平均年龄为22.6岁。所有患者均有颈部淋巴结病；3例有其他部位淋巴结病。4例患者发热超过39摄氏度。其中2例有脾肿大，3例报告有体重减轻。5例患者中有3例疾病复发，接受了类固醇或非甾体抗炎药治疗。所有患者均通过淋巴结切除活检确诊。
每一位发热且有淋巴结病的年轻患者都必须考虑菊池病。该疾病通常病程良性。
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