Singh Amit K, Tiwari Anil K, Singh Pratap B, Dwivedi Udai S, Trivedi Sameer, Singh Surya K, Agrawal Neeraj K, Deshpande Shripad B
Department of Physiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi.
Indian J Physiol Pharmacol. 2010 Apr-Jun;54(2):157-63.
The study was undertaken to evaluate the efficacy of multivitamin and micronutrient supplementation in azoospermic patients with maturation arrest. A total of 35 azoospermic patients showing maturation arrest on testicular biopsy were recruited in this study. The patients were divided into two groups. Untreated group (n=11) without any treatment and treated group (n=24) who received multivitamins, micronutrients and co-enzyme Q10. The sperm concentration, motility and morphology were evaluated at monthly interval. The results showed reduction in liquefaction time and relative viscosity of the semen in the treated group. Further, in treated group there was appearance of spermatozoa (4.0 million/ml) exhibiting progressive motility (7%) and normal morphology (6%), even in the first follow up visit. The sperm count, motility and normal morphology increased significantly on subsequent visits. Within 3 months (3 visits) 2 pregnancies were reported. These observations indicate that multivitamin and micronutrient supplementation improve the qualitative and quantitative parameters of seminogram in patients with azoospermia of maturation arrest.
本研究旨在评估多种维生素和微量营养素补充剂对成熟停滞的无精子症患者的疗效。本研究共招募了35例经睾丸活检显示成熟停滞的无精子症患者。患者被分为两组。未治疗组（n = 11）未接受任何治疗，治疗组（n = 24）接受多种维生素、微量营养素和辅酶Q10治疗。每月评估精子浓度、活力和形态。结果显示，治疗组精液的液化时间和相对粘度降低。此外，在治疗组中，即使在首次随访时，也出现了精子（400万/ml），其具有进行性活力（7%）和正常形态（6%）。在随后的随访中，精子计数、活力和正常形态显著增加。在3个月内（3次随访），报告了2例妊娠。这些观察结果表明，补充多种维生素和微量营养素可改善成熟停滞的无精子症患者精液检查的定性和定量参数。
