Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, USA.
Org Lett. 2010 Dec 17;12(24):5783-5. doi: 10.1021/ol102717x. Epub 2010 Nov 19.
A method for the cross-coupling of alkyl electrophiles with various potassium aryl- and heteroaryltrifluoroborates has been developed. Nearly stoichiometric amounts of organoboron species could be employed to cross-couple a large variety of challenging heteroaryl nucleophiles. Several functional groups were tolerated on both the electrophilic and the nucleophilic partners. Chemoselective reactivity of C(sp(3))-Br bonds in the presence of C(sp(2))-Br bonds was achieved.
一种烷基亲电试剂与各种钾芳基和杂芳基三氟硼酸盐的交叉偶联方法已经开发出来。几乎化学计量的有机硼物种可以用于交叉偶联各种具有挑战性的杂芳基亲核试剂。亲电体和亲核体上都可以容忍几个官能团。在 C(sp(2))-Br 键存在的情况下,C(sp(3))-Br 键的化学选择性反应得到了实现。