Department of Chemistry, The State University of New York at Buffalo, 14260, USA.
Angew Chem Int Ed Engl. 2012 Apr 16;51(16):3923-7. doi: 10.1002/anie.201109044. Epub 2012 Mar 5.
Problem solved: the title reaction was used for the synthesis of chiral 2-bromo, chloro, and iodomethyl indolines and 2-iodomethyl pyrrolidines. Stereocenter formation is believed to occur by enantioselective cis aminocupration and C-X bond formation is believed to occur by atom transfer. The ultility of the products as versatile synthetic intermediates was demonstrated, as was a radical cascade cyclization sequence.
该标题反应被用于合成手性 2-溴、氯和碘甲基吲哚啉和 2-碘甲基吡咯烷。据信，立体中心的形成是通过对映选择性顺氨铜化，而 C-X 键的形成是通过原子转移。该产物作为多功能合成中间体的实用性已得到证明，还展示了自由基级联环化序列。
