OSW-1 及其同系物的三维结构。
Three-dimensional structures of OSW-1 and its congener.
机构信息
Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, Tokyo, 184-8588, Japan.
出版信息
Org Lett. 2010 Dec 17;12(24):5732-5. doi: 10.1021/ol1025519. Epub 2010 Nov 23.
PMID:21090784
Abstract
The 3D structures of an antitumor glycosylsterol OSW-1 and its closely related congener were investigated by NMR studies and an X-ray crystallographic analysis. The disaccharide moiety was found as a structural scaffold for the formation of a hydrophobic cluster by the biologically required functionalities.
摘要
通过 NMR 研究和 X 射线晶体学分析，研究了一种抗肿瘤糖基甾醇 OSW-1 及其密切相关的同系物的 3D 结构。该二糖部分被发现为生物必需功能形成疏水性簇的结构支架。
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