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三种带有不同保护基团的麦芽糖侧链的OSW-1类似物的合成。

Synthesis of three OSW-1 analogs with maltose side chains bearing different protection groups.

作者信息

Guan Yu-Yao, Song Chao, Lei Ping-Sheng

机构信息

a State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Sciences , Peking , 100050 , China.

出版信息

J Asian Nat Prod Res. 2014 Jan;16(1):43-52. doi: 10.1080/10286020.2013.863185. Epub 2013 Dec 6.

Abstract

In order to simplify the synthesis of OSW-1's disaccharide side chain and explore the structure-activity relationship of OSW-1, three 16α-O-maltose OSW-1 analogs carrying three maltose side chains bearing different protections were designed and synthesized.

摘要

为了简化OSW-1二糖侧链的合成并探索OSW-1的构效关系,设计并合成了三种带有不同保护基的三麦芽糖侧链的16α-O-麦芽糖OSW-1类似物。

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