A、B环截短型OSW皂苷类似物的合成及其抗肿瘤活性。
Synthesis of the A,B-ring-truncated OSW saponin analogs and their antitumor activities.
作者信息
Peng Wenjie, Tang Pingping, Hu Xiaoyi, Liu Jun O, Yu Biao
机构信息
State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.
出版信息
Bioorg Med Chem Lett. 2007 Oct 15;17(20):5506-9. doi: 10.1016/j.bmcl.2007.08.060. Epub 2007 Aug 29.
PMID:17826089
Abstract
The A,B-ring-truncated OSW saponin analogs (1, 18a, and 18b) were synthesized. These greatly simplified trans-hydrindane disaccharides retained considerable inhibitory activity against the growth of HeLa and Jurkat T cells (IC(50)=0.8-21.1 microM).
摘要
合成了A、B环截短的OSW皂苷类似物（1、18a和18b）。这些大大简化的反式氢化茚二糖对HeLa细胞和Jurkat T细胞的生长仍保留相当的抑制活性（IC(50)=0.8 - 21.1微摩尔）。
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