Kumar Radhika L, Cruzat Andrea, Hamrah Pedram
Ocular Surface Imaging Center, Cornea & Refractive Surgey Service, Massachusetts Eye & Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
Semin Ophthalmol. 2010 Sep-Nov;25(5-6):166-70. doi: 10.3109/08820538.2010.518516.
The purpose of this study was to review the current literature on in vivo confocal microscopy of the cornea and to discuss the current clinical indications for its use in microbial keratitis.
Review of select recent literature on in vivo confocal microscopy and atypical microbial keratitis.
Delayed diagnosis of Acanthamoeba and fungal keratitis is typical, resulting in significant vision loss. This is partially due to the low sensitivity and time delay of corneal cultures. In the hands of an experienced viewer, the confocal microscope has been found to have a sensitivity of up to 90% in the diagnosis of Acanthamoeba keratitis and close to 80% for fungal keratitis.
In vivo confocal microscopy is emerging as a tool for rapid diagnoses in severe infectious keratitis with high sensitivity. In addition, it can be used to monitor treatment response, allowing guidance to clinicians for medical or surgical management.
本研究旨在回顾当前关于角膜活体共聚焦显微镜检查的文献，并讨论其在微生物性角膜炎中应用的当前临床指征。
回顾近期有关活体共聚焦显微镜检查和非典型微生物性角膜炎的部分文献。
棘阿米巴角膜炎和真菌性角膜炎的诊断通常会延迟，导致严重视力丧失。这部分归因于角膜培养的低敏感性和时间延迟。在经验丰富的观察者手中，共聚焦显微镜在诊断棘阿米巴角膜炎时的敏感性高达90%，诊断真菌性角膜炎时接近80%。
活体共聚焦显微镜检查正逐渐成为一种用于快速诊断严重感染性角膜炎的工具，具有高敏感性。此外，它可用于监测治疗反应，为临床医生的药物或手术治疗管理提供指导。
