Department of Periodontology, Dental School, University of Turin, Turin, Italy.
J Periodontol. 2011 Jun;82(6):845-53. doi: 10.1902/jop.2010.100468. Epub 2010 Nov 23.
Data concerning treatment outcomes in patients with generalized aggressive periodontitis (GAgP) are limited. The aim of this study is to investigate 6-month clinical and microbiologic outcomes of the one-stage full-mouth disinfection (OSFMD) in the management of patients with GAgP.
Twenty-seven patients with advanced GAgP were included in this prospective follow-up intervention study. Clinical and microbiologic parameters were collected at baseline and 3 and 6 months after the OSFMD. Patient-, tooth-, and site-level analyses were carried out. Subgingival samples from moderate (4 to 5 mm) and deep (≥6 mm) pocket sites were analyzed using a polymerase chain reaction for Aggregatibacter actinomycetemcomitans (previously Actinobacillus actinomycetemcomitans), Prevotella intermedia, Porphyromonas gingivalis, Tannerella forsythia (previously T. forsythensis), and Treponema denticola.
The OSFMD resulted in significant improvements in all parameters. After 6 months, the whole-mouth probing depth (PD) decreased from 4.2 ± 1.1 mm to 2.8 ± 0.6 mm, and the clinical attachment level was reduced from 4.5 ± 1.2 mm to 3.4 ± 1.1 mm (P <0.001). When data were analyzed based on the frequency distribution of PD, the number of sites with PD ≥5 mm decreased by 61% from baseline values, and mean PD reductions of 1.5 and 2.5 mm were noted in moderate and deep pockets, respectively. At 6 months, percentages of moderate and deep sites free of pathogens were 40% and 27%, respectively.
The OSFMD may be a viable approach to deal with severe GAgP.
关于广泛性侵袭性牙周炎（GAgP）患者治疗效果的数据有限。本研究旨在调查一次性全口消毒（OSFMD）治疗 GAgP 患者的 6 个月临床和微生物学效果。
本前瞻性随访干预研究纳入了 27 例患有晚期 GAgP 的患者。在 OSFMD 后 3 个月和 6 个月时采集临床和微生物学参数。进行患者、牙齿和部位水平分析。使用聚合酶链反应（PCR）分析中度（4 至 5 毫米）和深度（≥6 毫米）袋位的龈下样本，以检测伴放线放线杆菌（以前为放线杆菌）、中间普氏菌、牙龈卟啉单胞菌、福赛坦纳氏菌（以前为福赛坦纳氏菌）和齿密螺旋体。
OSFMD 使所有参数均显著改善。6 个月后，全口探诊深度（PD）从 4.2 ± 1.1 毫米降至 2.8 ± 0.6 毫米，临床附着水平从 4.5 ± 1.2 毫米降至 3.4 ± 1.1 毫米（P <0.001）。基于 PD 的频率分布进行数据分析时，PD≥5 毫米的位点数量减少了 61%，中度和深度袋的平均 PD 减少分别为 1.5 毫米和 2.5 毫米。6 个月时，中度和深度无病原体位点的百分比分别为 40%和 27%。
OSFMD 可能是治疗严重 GAgP 的可行方法。
