Department of Periodontology, Faculty of Dental Medicine, Al-Azhar University, Cairo, Egypt.
J Periodontol. 2011 May;82(5):751-7. doi: 10.1902/jop.2010.100523. Epub 2010 Nov 23.
The main objective of the present study was to quantify chlorhexidine (CHX) release after the use of CHX-EDTA root surface treatment as a local-delivery antimicrobial vehicle.
Twenty non-smoking patients clinically diagnosed as having moderate-to-severe chronic periodontitis were selected to participate in this study. After cause-related therapy, one site in every patient received defect overfill with CHX gel 2% (20 sites). In addition, twenty contralateral sites received defect fill of CHX gel after 3 minutes of 24% EDTA gel root surface etching (20 sites). Gingival crevicular fluid samples were collected at 1, 3, 7, and 14 days post-therapy.
The CHX-EDTA group showed statistically significantly higher levels of CHX than those of the control group at 1, 3, and 7 days. At 14 days, the CHX-EDTA group showed 0.8 mg/mL values.
The use of CHX-EDTA root surface treatment as a local-delivery antimicrobial improves CHX substantivity.
本研究的主要目的是量化使用 CHX-EDTA 根面处理作为局部抗菌药物后洗必泰（CHX）的释放情况。
选择 20 名非吸烟患者，临床诊断为中重度慢性牙周炎。每位患者的一个部位接受 CHX 凝胶 2%（20 个部位）的过度填充。此外，在 24% EDTA 凝胶根面蚀刻后 3 分钟，20 个对侧部位接受 CHX 凝胶的缺陷填充。在治疗后 1、3、7 和 14 天收集龈沟液样本。
CHX-EDTA 组在第 1、3 和 7 天的 CHX 水平明显高于对照组。在第 14 天，CHX-EDTA 组的 CHX 值为 0.8mg/mL。
使用 CHX-EDTA 根面处理作为局部抗菌药物可以提高 CHX 的持续性。
