Department of Biotechnology, University of Kashmir, Jammu and Kashmir, India.
Biomarkers. 2011 Feb;16(1):31-6. doi: 10.3109/1354750X.2010.522731. Epub 2010 Nov 24.
We studied the expression of α1-syntrophin (SNTA1) protein in histologically confirmed esophageal, stomach, lung, colon, rectal and breast cancerous tissue samples. Our results suggest a significant decrease in the expression level of SNTA1 protein in both esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC) compared with their respective controls while a significant increase in expression of SNTA1 protein compared with the normal tissue was observed in breast carcinoma samples. No significant difference in expression of SNTA1 protein was observed in stomach, lung, colon and rectal cancers. Our results suggest that SNTA1 has a role in carcinogenesis and could possibly be used as a novel diagnostic or prognostic marker in esophageal and breast cancers.
我们研究了α1- 连接蛋白（SNTA1）在组织学上证实的食管、胃、肺、结肠、直肠和乳腺癌组织样本中的表达。我们的结果表明，与各自的对照相比，食管鳞状细胞癌（ESCC）和食管腺癌（EAC）中 SNTA1 蛋白的表达水平显著降低，而在乳腺癌样本中，与正常组织相比，SNTA1 蛋白的表达水平显著增加。在胃癌、肺癌、结肠癌和直肠癌中，SNTA1 蛋白的表达没有显著差异。我们的结果表明，SNTA1 在癌症发生中起作用，可能可作为食管癌和乳腺癌的新型诊断或预后标志物。
