Poursafa Parinaz, Kelishadi Roya
Tehran Azad University, Science and Research Branch, Tehran, Iran.
Inflamm Allergy Drug Targets. 2010 Dec;9(5):387-92. doi: 10.2174/187152810793937982.
Atherosclerosis begins in early life. The role of platelets is well-documented from its early stages. A wealth of evidence associates atherosclerotic cardiovascular disease with inflammatory diseases. The role of environmental factors, including air pollution, remains overlooked. Some studies have documented the effect of air pollution on inflammatory and pro-thrombotic factors implicated in the progression of cardiovascular diseases. In particular, the increase of platelet count and platelet hyper-reactivity towards agonists are emerging as markers of hematologic and hemostatic changes in response to the exposure to air pollutants. The systemic pro-inflammatory and pro-thrombotic response to the inhalation of fine and ultrafine particulate matters is seemingly associated with platelet activation. This association may have a clinical significance, particularly in the presence of cardiometabolic risk factors, and may indicate the need for anti-platelet treatment. It is of particular relevance to further study the significance of platelet activation and anti-platelet therapies in primordial/primary preventive measures in children and adolescents at risk of accelerated atherosclerosis.
动脉粥样硬化始于生命早期。血小板在其早期阶段的作用已有充分记录。大量证据将动脉粥样硬化性心血管疾病与炎症性疾病联系起来。包括空气污染在内的环境因素的作用仍被忽视。一些研究记录了空气污染对涉及心血管疾病进展的炎症和促血栓形成因子的影响。特别是，血小板计数的增加以及血小板对激动剂的高反应性正逐渐成为暴露于空气污染物后血液学和止血变化的标志物。吸入细颗粒物和超细颗粒物后的全身促炎和促血栓形成反应似乎与血小板活化有关。这种关联可能具有临床意义，尤其是在存在心脏代谢危险因素的情况下，并且可能表明需要进行抗血小板治疗。进一步研究血小板活化和抗血小板治疗在有动脉粥样硬化加速风险的儿童和青少年的一级/初级预防措施中的意义尤为重要。
