Liu Junling, Wang Pei, Shang Lv, Ye Fang, Liu Li, He Zhenyu
Wuhan Center for Disease Control and Prevention, Wuhan 430024, China.
School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Toxics. 2024 Jul 23;12(8):529. doi: 10.3390/toxics12080529.
Air purifier use, shift work, and long-term exposure to fine particulate matter (PM) are linked to platelet abnormality. However, the role of air purifier use and shift work in the individual or joint associations of PM and its components with platelet indices are largely unknown. A total of 8772 participants were recruited from a population of subway workers in China. PM and its component data were obtained from the Tracking Air Pollution in China dataset. The role of air purifier use and shift work in the association between PM and its components and platelet indices were analyzed. Among shift workers without air purifier use, positive associations of PM and each component in PM with the mean platelet volume (MPV) or platelet counts (PLT) were observed, whereas negative associations of PM and each component in PM with the platelet distribution width (PDW) were observed. Furthermore, estimated changes (95%CIs) in PLT, MPV, and PDW in response to each 10th percentile increment in the mixture of PM and its components were 0.8657 (0.2496, 1.4819), 0.0192 (0.0054, 0.0329), and -0.0648 (-0.0945, -0.0351), respectively, and sulfate in PM was the major contributor to those associations. Long-term exposure to PM and its components was related to increased platelet disorders among shift workers without air purifier use, and those associations were mainly attributed to sulfate in PM.
使用空气净化器、轮班工作以及长期暴露于细颗粒物（PM）与血小板异常有关。然而，使用空气净化器和轮班工作在PM及其成分与血小板指标的个体或联合关联中的作用在很大程度上尚不清楚。在中国地铁工人人群中总共招募了8772名参与者。PM及其成分数据来自中国空气污染追踪数据集。分析了使用空气净化器和轮班工作在PM及其成分与血小板指标之间关联中的作用。在未使用空气净化器的轮班工人中，观察到PM及其各成分与平均血小板体积（MPV）或血小板计数（PLT）呈正相关，而PM及其各成分与血小板分布宽度（PDW）呈负相关。此外，PM及其成分混合物每增加第十百分位数时，PLT、MPV和PDW的估计变化（95%置信区间）分别为0.8657（0.2496，1.4819）、0.0192（0.0054，0.0329）和-0.0648（-0.0945，-0.0351），并且PM中的硫酸盐是这些关联的主要促成因素。长期暴露于PM及其成分与未使用空气净化器的轮班工人中血小板紊乱增加有关，并且这些关联主要归因于PM中的硫酸盐。
