Department of Clinical Microbiology 445, MRSA Knowledge Center, Hvidovre Hospital, Hvidovre, Denmark.
FEMS Microbiol Lett. 2011 Jan;314(1):101-5. doi: 10.1111/j.1574-6968.2010.02151.x. Epub 2010 Nov 19.
Very little is known about how the spa gene mutates over time in methicillin-resistant Staphylococcus aureus (MRSA) from the same patient. Copenhagen is an area with low prevalence of MRSA but with high variability in spa types. We collected 1536 MRSA isolates from 319 patients during a 5-year period and found spa type alterations in 30 MRSA isolates (2%) from 13 patients (4%). The alteration most often seen was the deletion of repeats followed by repeat duplication and point mutation.
关于来自同一患者的耐甲氧西林金黄色葡萄球菌 (MRSA) 中 spa 基因随时间如何发生突变，人们知之甚少。哥本哈根是一个 MRSA 发病率较低但 spa 型别变异较大的地区。我们在 5 年期间从 319 名患者中收集了 1536 株 MRSA 分离株，在 13 名患者（4%）的 30 株 MRSA 分离株（2%）中发现 spa 型别改变。最常见的改变是重复序列缺失，其次是重复序列重复和点突变。
