EFSA J. 2019 Feb 27;17(2):e05598. doi: 10.2903/j.efsa.2019.5598. eCollection 2019 Feb.
The data on antimicrobial resistance in zoonotic and indicator bacteria in 2017, submitted by 28 EU Member States (MSs), were jointly analysed by EFSA and ECDC. Resistance in zoonotic and from humans, animals and food, and resistance in indicator as well as meticillin-resistant in animals and food were addressed, and temporal trends assessed. 'Microbiological' resistance was assessed using epidemiological cut-off (ECOFF) values; for some countries, qualitative data on human isolates were interpreted in a way which corresponds closely to the ECOFF-defined 'microbiological' resistance. In from humans, as well as in and isolates from fattening pigs and calves of less than 1 year of age, high proportions of isolates were resistant to ampicillin, sulfonamides and tetracyclines, whereas resistance to third-generation cephalosporins was uncommon. Varying occurrence/prevalence rates of presumptive extended-spectrum beta-lactamase (ESBL)/AmpC producers in and monitored in meat (pork and beef), fattening pigs and calves, and monitored in humans, were observed between countries. Carbapenemase-producing were detected in one single sample from fattening pigs in one MS. Resistance to colistin was observed at low levels in and from fattening pigs and calves and meat thereof and in from humans. In from humans, high to extremely high proportions of isolates were resistant to ciprofloxacin and tetracyclines, particularly in . In five countries, high to very high proportions of from humans were resistant also to erythromycin, leaving few options for treatment of severe infections. High resistance to ciprofloxacin and tetracyclines was observed in isolates from fattening pigs, whereas much lower levels were recorded for erythromycin. Combined resistance to critically important antimicrobials in both human and animal isolates was generally uncommon but very high to extremely high multidrug resistance levels were observed in . Typhimurium and its monophasic variant in both humans and animals. . Kentucky from humans exhibited high-level resistance to ciprofloxacin, in addition to a high prevalence of ESBL.
2017年,28个欧盟成员国提交了人畜共患病和指示菌的抗菌药物耐药性数据,由欧洲食品安全局(EFSA)和欧洲疾病预防控制中心(ECDC)联合分析。研究涉及人畜共患病菌在人与动物及食物中的耐药性、指示菌的耐药性以及动物和食物中耐甲氧西林菌的耐药性,并评估了时间趋势。使用流行病学临界值(ECOFF)评估“微生物学”耐药性;对于一些国家,人类分离株的定性数据以与ECOFF定义的“微生物学”耐药性密切对应的方式进行解读。在人类分离株中,以及在1岁以下育肥猪和犊牛的分离株中,很大比例的分离株对氨苄西林、磺胺类药物和四环素耐药,而对第三代头孢菌素耐药的情况并不常见。各国在肉类(猪肉和牛肉)、育肥猪和犊牛中监测的以及在人类中监测的推定产超广谱β-内酰胺酶(ESBL)/AmpC菌的发生率/流行率各不相同。在一个成员国的一头育肥猪的单个样本中检测到产碳青霉烯酶菌。在育肥猪及其肉类以及人类的分离株中,观察到对黏菌素的低水平耐药。在人类分离株中,很大比例到极高比例的分离株对环丙沙星和四环素耐药,特别是在[具体地区未提及]。在五个国家,很大比例到非常高比例的人类分离株对红霉素也耐药,使得严重[感染类型未提及]感染的治疗选择很少。在育肥猪的分离株中观察到对环丙沙星和四环素的高耐药性,而对红霉素的耐药水平则低得多。人类和动物分离株中对极其重要的抗菌药物的联合耐药通常并不常见,但在[具体情况未提及]中观察到非常高到极高的多重耐药水平。人类和动物中的鼠伤寒沙门氏菌及其单相变体。人类中的肯塔基沙门氏菌除了ESBL流行率高外,还对环丙沙星表现出高水平耐药。