Blood Transfusion Centre, Swiss Red Cross, Basel, Switzerland.
Vox Sang. 2011 Apr;100(3):303-11. doi: 10.1111/j.1423-0410.2010.01427.x. Epub 2010 Nov 23.
Blood donation can contribute to iron deficiency. The possibly resulting anaemia importantly affects donor return rate. The determination of serum ferritin levels revealed iron deficiency in many non-anaemic premenopausal female blood donors at our Institution. We started an iron substitution programme targeting this donor group to prevent anaemia and enhance donor retain.
Women aged≤50 with haemoglobin levels adequate for donation and serum ferritin≤10 ng/ml were offered iron supplementation. Substitution lasted 16 weeks and the donation interval was extended. History collection including iron deficiency-related symptoms, whole blood count and serum ferritin determination was performed at baseline and after 2 and 6 months. Data were recorded prospectively and compared with those of 108 female controls with iron deficiency not receiving iron substitution (retrospective data).
Of the 116 participating subjects, 60% completed the programme. Significant results were serum ferritin increase (from a mean value of 7.12 to 25.2 ng/ml), resolution of prostration, fatigue, sleep disturbances, tension in the neck, hair loss and nail breakage. No case of anaemia occurred. Sixty per cent of the women completed the programme and donated blood again.
Targeted iron substitution prevents the development of anaemia and enhances donation return in premenopausal female blood donors with iron deficiency.
献血可能导致缺铁。由此导致的贫血会显著影响献血者的返回率。我们机构的研究发现，许多非贫血的绝经前女性献血者的血清铁蛋白水平显示缺铁。我们针对这一献血者群体开展了一项铁替代计划，以预防贫血并提高献血者保留率。
血红蛋白水平适合献血且血清铁蛋白水平≤10ng/ml 的≤50 岁女性献血者被提供铁补充剂。替代治疗持续 16 周，并延长献血间隔。在基线、治疗 2 个月和 6 个月时进行病史采集，包括缺铁相关症状、全血细胞计数和血清铁蛋白测定。数据被前瞻性记录，并与 108 名未接受铁替代治疗的缺铁女性对照组（回顾性数据）进行比较。
116 名参与研究的女性中，60%完成了治疗方案。血清铁蛋白显著增加（从平均 7.12ng/ml 增加到 25.2ng/ml），乏力、疲劳、睡眠障碍、颈部紧张、脱发和指甲断裂等症状得到缓解。没有发生贫血病例。60%的女性完成了治疗方案并再次献血。
针对缺铁的绝经前女性献血者进行铁替代治疗可预防贫血的发生并提高献血者的返回率。
