Department of Radiology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200127, China.
J Neuroimaging. 2011 Oct;21(4):370-4. doi: 10.1111/j.1552-6569.2010.00535.x. Epub 2010 Nov 17.
Essential tremor (ET) is suggested to be a neural degenerative disease. The authors investigated the fractional anisotropy (FA) and apparent diffusion coefficient (ADC) value in basal ganglia, thalamus, red nucleus, and substantia nigra in ET patients using diffusion tensor image (DTI).
DTI examination was carried out in patients with ET and controls. FA and ADC values were obtained from various brain structures, including caudate, putamen+pallidum, thalamus, red nucleus, and substantia nigra.
The ADC value of the red nuclei in patients with ET was higher compared with controls (.90 vs .77; P= .000). However, no significant differences were demonstrated for FA, or ADC values of other structures.
The increased ADC value in the red nucleus indicates that there is neuronal damage or loss present, suggesting that ET may be a neurodegenerative disease.
特发性震颤（ET）被认为是一种神经退行性疾病。作者使用弥散张量成像（DTI）研究了 ET 患者基底节、丘脑、红核和黑质的各向异性分数（FA）和表观扩散系数（ADC）值。
对 ET 患者和对照组进行了 DTI 检查。从尾状核、壳核+苍白球、丘脑、红核和黑质等不同脑结构获得 FA 和 ADC 值。
ET 患者红核的 ADC 值高于对照组（.90 比.77；P=.000）。然而，其他结构的 FA 或 ADC 值没有显著差异。
红核的 ADC 值增加表明存在神经元损伤或丢失，提示 ET 可能是一种神经退行性疾病。
