Department of Neurology, Lahey Clinic, Lexington, MA 02421, USA.
J Neuroimaging. 2012 Jan;22(1):38-41. doi: 10.1111/j.1552-6569.2010.00538.x. Epub 2010 Nov 17.
To investigate the incidence, characteristics, and predisposing factors for cerebral white matter lesions in patients with Crohn's disease.
We retrospectively evaluated the incidence and characteristics of cerebral T2 white matter abnormalities in 54 patients with Crohn's disease and compared to 100 age-matched controls. We also investigated potential co-morbidities known to be associated with white matter abnormalities in Crohn's patients with normal and abnormal Magnetic Resonance Imaging (MRI).
Seventy-two percent of patients with Crohn's disease had T2 white matter abnormalities, as compared with 34% of the age-matched controls (P < .001). Lesion severity and size were not significantly different between the two groups; however, periventricular distribution and fulfillment of the Barkhof MRI criteria were overrepresented in Crohn's population. History of hypertension, diabetes, and migraine; gender, duration of disease and prior exposure to anti-tumor necrosis factor were not significantly different between Crohn's patients with and without white matter abnormalities; however, patients with lesions were significantly older than those without.
Patients with Crohn's disease have a higher incidence of white matter T2 hyperintensities as compared with controls. Age was the only significant factor for the abnormalities within Crohn's group. White matter T2 hyperintensities are likely another extra-intestinal manifestation of Crohn's disease.
研究克罗恩病患者脑白质病变的发生率、特征和易患因素。
我们回顾性评估了 54 例克罗恩病患者脑 T2 白质异常的发生率和特征，并与 100 例年龄匹配的对照组进行了比较。我们还研究了与克罗恩病患者磁共振成像（MRI）正常和异常相关的潜在共病，以探讨这些共病与脑白质异常的关系。
72%的克罗恩病患者存在 T2 白质异常，而年龄匹配的对照组为 34%（P<0.001）。两组间病变严重程度和大小无显著差异；然而，在克罗恩病患者中，脑室周围分布和 Barkhof MRI 标准的符合率较高。高血压、糖尿病和偏头痛的病史；性别、疾病持续时间和以前接触过抗肿瘤坏死因子在克罗恩病患者中存在白质异常和无白质异常之间无显著差异；然而，有病变的患者明显比没有病变的患者年龄大。
与对照组相比，克罗恩病患者脑白质 T2 高信号的发生率较高。年龄是克罗恩病组中异常的唯一显著因素。脑白质 T2 高信号可能是克罗恩病的另一种肠外表现。
