Department of Medical Sciences, School of Veterinary Medicine, The University of Wisconsin-Madison, Madison, WI 53706, USA.
J Vet Intern Med. 2011 Jan-Feb;25(1):39-46. doi: 10.1111/j.1939-1676.2010.0638.x. Epub 2010 Nov 23.
Nonsteroidal anti-inflammatory drugs frequently cause gastrointestinal (GI) injury. Zinc-L-carnosine has antioxidant, anti-inflammatory, mucosal protective, and healing properties in rodent models and in some human studies of GI injury.
The combination of zinc-L-carnosine and vitamin E attenuates aspirin-induced gastroduodenal mucosal injury.
Eighteen healthy random-source Foxhound dogs.
In this randomized, double-blinded, placebo-controlled study dogs were treated with placebo (n = 6; 0X group), 30 mg/30 IU (n = 6; 1X group), or 60 mg/60 IU (n = 6; 2X group) zinc-L-carnosine/vitamin E orally every 12 hours for 35 days. Between Day 7 and 35, GI mucosal lesions were induced with aspirin (25 mg/kg p.o. q8h). Mucosal injury lesions (hemorrhage, erosion, and ulcer) were assessed by gastroduodenoscopy on Days 14, 21, and 35 with a 12-point scoring scale.
At baseline (Day -1) gastroscopy scores were not significantly different between groups (mean ± SD: 0X, 4.4 ± 0.8; group 1X, 4.4 ± 0.6; group 2X, 4.2 ± 0.3; P= .55). Gastroscopy scores increased significantly in all groups between Day -1 and Days 14, 21, and 35 (P < .0001). On Day 35, gastroscopy scores were 29.2 ± 5.2 (0X), 27.3 ± 3.7 (1X), and 28.6 ± 3.3 (2X). Mean gastroscopy scores were not significantly different among treatment groups on any of the days (P = .61).
Administration of the combination of zinc-L-carnosine and vitamin E at 1X or 2X dosing did not attenuate aspirin-induced gastroduodenal mucosal injury.
非甾体抗炎药常引起胃肠道（GI）损伤。锌-L-肉碱在啮齿动物模型和一些胃肠道损伤的人体研究中具有抗氧化、抗炎、粘膜保护和愈合特性。
锌-L-肉碱和维生素 E 的联合使用可减轻阿司匹林引起的胃十二指肠粘膜损伤。
18 只健康的随机来源的猎狐犬。
在这项随机、双盲、安慰剂对照研究中，狗每天口服安慰剂（n = 6；0X 组）、30mg/30IU（n = 6；1X 组）或 60mg/60IU（n = 6；2X 组）锌-L-肉碱/维生素 E，每 12 小时一次，共 35 天。在第 7 天至第 35 天期间，用阿司匹林（25mg/kg，口服，每 8 小时一次）诱导胃十二指肠粘膜损伤。在第 14、21 和 35 天，用 12 分制评分量表通过胃镜评估粘膜损伤病变（出血、糜烂和溃疡）。
在基线（第-1 天）时，各组的胃镜评分无显著差异（平均值 ± SD：0X，4.4 ± 0.8；1X 组，4.4 ± 0.6；2X 组，4.2 ± 0.3；P =.55）。在所有组中，从第-1 天到第 14、21 和 35 天，胃镜评分均显著增加（P <.0001）。在第 35 天，胃镜评分分别为 29.2 ± 5.2（0X）、27.3 ± 3.7（1X）和 28.6 ± 3.3（2X）。在任何一天，治疗组之间的平均胃镜评分均无显著差异（P =.61）。
以 1X 或 2X 剂量给予锌-L-肉碱和维生素 E 的联合治疗并未减轻阿司匹林引起的胃十二指肠粘膜损伤。
