心肌梗死后心室肌纤维的三维结构
Three-dimension structure of ventricular myocardial fibers after myocardial infarction.
作者信息
Gao Changqing, Ye Weihua, Li Libin
机构信息
Department of Cardiovascular Surgery, PLA General Hospital, 28 Fuxing Road, Beijing 100853, PR China.
出版信息
J Cardiothorac Surg. 2010 Nov 23;5:116. doi: 10.1186/1749-8090-5-116.
BACKGROUND
To explore the pathological changes of three-dimension structure of ventricular myocardial fibers after anterior myocardial infarction in dog heart.
METHODS
Fourteen acute anterior myocardial infarction models were made from healthy dogs (mean weight 17.6 ± 2.5 kg). Six out of 14 dogs with old myocardial infarction were sacrificed, and their hearts were harvested after they survived the acute anterior myocardial infarction for 3 months. Each heart was dissected into ventricular myocardial band (VMB), morphological characters in infarction region were observed, and infarct size percents in descending segment and ascending segment were calculated.
RESULTS
Six dog hearts were successfully dissected into VMB. Uncorresponding damages in myocardial fibers of descending segment and ascending segment were found in apical circle in anterior wall infarction. Infarct size percent in the ascending segment was significantly larger than that in the descending segment (23.36 ± 3.15 (SD) vs 30.69 ± 2.40%, P = 0.0033); the long axis of infarction area was perpendicular to the orientation of myocardial fibers in ascending segment; however, the long axis of the infarction area was parallel with the orientation of myocardial fibers in descending segment.
CONCLUSIONS
We found that damages were different in both morphology and size in ascending segment and descending segment in heart with myocardial infarction. This may provide an important insight for us to understand the mechanism of heart failure following coronary artery diseases.
背景
探讨犬心脏前壁心肌梗死后心室肌纤维三维结构的病理变化。
方法
选用14只健康犬（平均体重17.6±2.5kg）制作急性前壁心肌梗死模型。14只犬中6只存活3个月后处死，取心脏，将每颗心脏解剖为心室肌束（VMB），观察梗死区域的形态特征，计算降支和升支的梗死面积百分比。
结果
成功解剖6只犬心脏获得VMB。前壁梗死心尖环处降支和升支心肌纤维损伤不对应。升支梗死面积百分比显著大于降支（23.36±3.15（标准差）对30.69±2.40%，P=0.0033）；梗死区长轴与升支心肌纤维走向垂直，而与降支心肌纤维走向平行。
结论
发现心肌梗死心脏的升支和降支在形态和大小上的损伤存在差异。这可能为我们理解冠状动脉疾病后心力衰竭的机制提供重要线索。
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