Cognitive Neuroscience Division of the Taub Institute, Columbia University College of Physicians and Surgeons, New York, New York, USA.
J Int Neuropsychol Soc. 2011 Jan;17(1):56-61. doi: 10.1017/S135561771000127X. Epub 2010 Nov 24.
Measures of brain and hippocampal volume in 40 healthy young (aged 18-30 years) and 36 healthy elderly (aged 60-83 years) subjects were compared with composite cognitive function scores in three conceptual domains: memory ability, processing speed, and general fluid intelligence. Through a series of general linear models testing the relationship between these brain measures and cognitive performance scores, a significant positive relationship between hippocampal volume and fluid intelligence ability was found in elderly subjects but not in young. No relationship between the other cognitive domains and brain or hippocampal volume was found. The findings suggest a role of hippocampal atrophy in the decline in fluid intelligence in the elderly.
比较了 40 名健康年轻人（年龄 18-30 岁）和 36 名健康老年人（年龄 60-83 岁）的大脑和海马体体积测量值与三个概念领域的综合认知功能评分：记忆能力、处理速度和一般流体智力。通过一系列测试这些大脑测量值与认知表现评分之间关系的一般线性模型，发现老年人的海马体体积与流体智力能力呈显著正相关，但年轻人则没有。在其他认知领域与大脑或海马体体积之间没有发现关系。研究结果表明，海马体萎缩在老年人流体智力下降中起作用。
