Li Yutao, Fu Chenyi, Song Honglin, Zhang Zhenhang, Liu Tianbiao
School of Physical Education and Sports Science, South China Normal University, Guangzhou, China.
College of Physical Education and Sports, Beijing Normal University, Beijing, China.
Front Aging Neurosci. 2024 Sep 20;16:1403464. doi: 10.3389/fnagi.2024.1403464. eCollection 2024.
This study investigates the causal relationship between moderate to vigorous physical activity and cognitive performance.
Genetic loci strongly related to moderate to vigorous physical activity from genome-wide association studies were used as instrumental variables. These were combined with genetic data on cognitive performance from different Genome-Wide Association Study (GWAS) to conduct a two-sample Mendelian randomization analysis. The primary analysis used inverse variance weighting within a random effects model, supplemented by weighted median estimation, MR-Egger regression and other methods, with results expressed as Beta coefficient.
This study selected 19 SNPs closely related to physical activity as instrumental variables. The multiplicative random-effects Inverse-Variance Weighted (IVW) analysis revealed that moderate to vigorous physical activity was negatively associated with cognitive performance (Beta = -0.551; OR = 0.58; 95% CI: 0.46-0.72; < 0.001). Consistent results were obtained using the fixed effects IVW model (Beta = -0.551; OR = 0.58; 95% CI: 0.52-0.63; < 0.001), weighted median (Beta = -0.424; OR = 0.65; 95% CI: 0.55-0.78; < 0.001), simple mode (Beta = -0.467; OR = 0.63; 95% CI: 0.44-0.90; < 0.001), and weighted mode (Beta = -0.504; OR = 0.60; 95% CI: 0.44-0.83; < 0.001). After adjusting for BMI, smoking, sleep duration, and alcohol intake frequency, the multivariate MR analysis also showed a significant association between genetically predicted MVPA and cognitive performance, with Beta of -0.599 and OR = 0.55 (95% CI: 0.44-0.69; < 0.001).
The findings of this study indicate that genetically predicted moderate to vigorous physical activity may be associated with a decline in cognitive performance.
本研究调查中度至剧烈身体活动与认知表现之间的因果关系。
将全基因组关联研究中与中度至剧烈身体活动密切相关的基因位点用作工具变量。将这些与来自不同全基因组关联研究（GWAS）的认知表现基因数据相结合，进行两样本孟德尔随机化分析。主要分析在随机效应模型中使用逆方差加权，并辅以加权中位数估计、MR-Egger回归等方法，结果以β系数表示。
本研究选择了19个与身体活动密切相关的单核苷酸多态性（SNP）作为工具变量。乘性随机效应逆方差加权（IVW）分析显示，中度至剧烈身体活动与认知表现呈负相关（β = -0.551；比值比[OR]=0.58；95%置信区间[CI]：0.46 - 0.72；P < 0.001）。使用固定效应IVW模型（β = -0.551；OR = 0.58；95% CI：0.52 - 0.63；P < 0.001）、加权中位数（β = -0.424；OR = 0.65；95% CI：0.55 - 0.78；P < 0.001）、简单模式（β = -0.467；OR = 0.63；95% CI：0.44 - 0.90；P < 0.001）和加权模式（β = -0.504；OR = 0.60；95% CI：0.44 - 0.83；P < 0.001）也得到了一致的结果。在调整体重指数、吸烟、睡眠时间和饮酒频率后，多变量孟德尔随机化分析也显示基因预测的中度至剧烈身体活动与认知表现之间存在显著关联，β为 -0.599，OR = 0.55（95% CI：0.44 - 0.69；P < 0.001）。
本研究结果表明，基因预测的中度至剧烈身体活动可能与认知表现下降有关。
