Department of Clinical and Molecular Hepatology, Institute of Medical Research A Lanari-IDIM, University of Buenos Aires-National Council of Scientific and Technological Research (CONICET), Ciudad Autónoma de Buenos Aires, Argentina.
Biol Psychol. 2011 Mar;86(3):153-7. doi: 10.1016/j.biopsycho.2010.11.003. Epub 2010 Nov 18.
We performed a study on a sample of 856 individuals to answer whether the pleasantness/unpleasantness of the odor perception of their partners (rating of partner odor) is associated with depression and anxiety. To evaluate the influence of common genetic variation of the odorant receptor OR7D4 on the rating of partner odor, the variant rs8109935 was genotyped in the whole sample. The rating of partner odor was significantly associated with scores of anxiety and depression. Depression (OR: 0.75, 95% CI: 0.56-0.98, p = 0.039) and anxiety (Robust Coef ± SE: -13 ± 0.6, p = 0.044) were inversely associated with pleasantness rating of partner odor. Ordered probit regression analysis shows that the rating of partner odor was significantly associated with the rs8109935 genotypes (Coef ± robust SE: 0.19 ± 0.09, p = 0.028). These findings suggest that odor perception between heterosexual partners may have an impact on the development of depression and anxiety, and that it might be influenced by genetic variation in OR7D4.
我们对 856 名个体进行了一项研究，以回答他们对伴侣气味感知的愉悦/不愉快程度（伴侣气味评分）是否与抑郁和焦虑有关。为了评估气味受体 OR7D4 的常见遗传变异对伴侣气味评分的影响，我们对整个样本进行了变体 rs8109935 的基因分型。伴侣气味评分与焦虑和抑郁评分显著相关。抑郁（OR：0.75，95%CI：0.56-0.98，p=0.039）和焦虑（稳健系数±SE：-13±0.6，p=0.044）与伴侣气味的愉悦评分呈负相关。有序概率回归分析表明，伴侣气味评分与 rs8109935 基因型显著相关（Coef±稳健 SE：0.19±0.09，p=0.028）。这些发现表明，异性伴侣之间的气味感知可能会对抑郁和焦虑的发展产生影响，并且可能受到 OR7D4 遗传变异的影响。
