Lemon Greg, Howard Daniel, Rose Felicity R A J, King John R
School of Mathematical Sciences, University of Nottingham, University Park, UK.
Biosystems. 2011 Mar;103(3):372-83. doi: 10.1016/j.biosystems.2010.11.009. Epub 2010 Nov 18.
This paper presents a simulation modelling framework to study the growth of blood vessels and cells through a porous tissue engineering scaffold. The model simulates the migration of capillaries and the formation of a vascular network through a single pore of a tissue engineering scaffold when it is embedded in living tissue. The model also describes how the flow of blood through the network changes as growth proceeds. Results are given for how the different strategies of seeding the pore with cells affects the extent of vascularisation. Also simulations are made to compare results where the values of different model parameters are varied such as the pore dimensions, the density of endothelial cells seeded into the pore, and the release rate of growth factor from the scaffold into the pore. The modelling framework described in this paper is useful for exploring experimental strategies for producing well-vascularised tissue engineered constructs, and is therefore potentially important to the field of regenerative medicine.
本文提出了一个模拟建模框架，用于研究血管和细胞在多孔组织工程支架中的生长情况。该模型模拟了将组织工程支架嵌入活组织时，毛细血管通过单个孔隙的迁移以及血管网络的形成。该模型还描述了随着生长过程的推进，血液在网络中的流动是如何变化的。给出了不同细胞接种策略对血管化程度影响的结果。此外，还进行了模拟，以比较不同模型参数值（如孔隙尺寸、接种到孔隙中的内皮细胞密度以及生长因子从支架释放到孔隙中的速率）变化时的结果。本文所述的建模框架对于探索制备血管化良好的组织工程构建体的实验策略很有用，因此对再生医学领域可能具有重要意义。
