Department of Emergency Medicine, Alpert Medical School of Brown, University Rhode Island Hospital & The Miriam Hospital, 593 Eddy Street, Claverick 2, Providence, RI 02903, USA.
Psychiatr Clin North Am. 2010 Dec;33(4):741-56. doi: 10.1016/j.psc.2010.08.005.
A complex set of molecular and functional reactions is set into motion by traumatic brain injury (TBI). New research that extends beyond pathological effects on neurons suggests a key role for the blood-brain barrier, neurovascular unit, arginine vasopressin, and neuroinflammation in the pathophysiology of TBI. The prevalence of molecular derangements in TBI holds promise for the identification and use of biomarkers to assess severity of injury, determine prognosis, and perhaps direct therapy. Hopefully, improved knowledge of these elements of pathophysiology will provide the mechanistic clues that lead to improved treatment of TBI.
创伤性脑损伤（TBI）会引发一系列复杂的分子和功能反应。新的研究表明，血脑屏障、神经血管单元、精氨酸加压素和神经炎症在 TBI 的病理生理学中起着关键作用，这超越了对神经元的病理影响。TBI 中分子紊乱的普遍性为鉴定和使用生物标志物来评估损伤严重程度、确定预后，甚至可能指导治疗提供了希望。希望对这些病理生理学因素的深入了解将提供导致 TBI 治疗改善的机制线索。
