Minerva Institute for Medical Research, Biomedicum-2 Helsinki, Tukholmankatu 8, FIN-00290 Helsinki, Finland.
Neurosci Lett. 2011 Jan 25;488(3):263-6. doi: 10.1016/j.neulet.2010.11.042. Epub 2010 Nov 19.
Resveratrol, a polyphenol derived e.g. from red grapes, has been shown to mediate several positive biological actions such as protection of cells against oxidative stress. It can also influence cell signaling, but the mechanisms behind its antioxidant properties are largely unknown. Here we show that RSV reduces oxidative stress and enhances cell survival in PC6.3 cells depending on the concentration. In these cells, RSV increased the levels of antioxidants, SOD2 and TRX2, and of X chromosome-linked inhibitor of apoptosis protein. RSV also activated NFκB signaling as shown using luciferase reporter constructs. These findings show that RSV regulates oxidative stress and mitochondrial antioxidants in neuronal cells. This may contribute to cell protection in various brain disorders.
白藜芦醇是一种多酚，例如来源于红葡萄，已被证明具有多种积极的生物学作用，如保护细胞免受氧化应激。它还可以影响细胞信号转导，但它的抗氧化特性的机制在很大程度上是未知的。在这里，我们表明 RSV 可以根据浓度降低 PC6.3 细胞中的氧化应激并增强细胞存活。在这些细胞中，RSV 增加了抗氧化剂 SOD2 和 TRX2 的水平，以及 X 染色体连锁的凋亡蛋白抑制剂的水平。RSV 还激活了 NFκB 信号转导，如使用荧光素酶报告基因构建体所示。这些发现表明 RSV 调节神经元细胞中的氧化应激和线粒体抗氧化剂。这可能有助于各种脑疾病中的细胞保护。
