肝脏铁的磁共振成像定量分析
Magnetic resonance imaging quantification of liver iron.
作者信息
Sirlin Claude B, Reeder Scott B
机构信息
Liver Imaging Group, Department of Radiology, University of California San Diego, 408 Dickinson Street, San Diego, CA 92103-8226, USA.
出版信息
Magn Reson Imaging Clin N Am. 2010 Aug;18(3):359-81, ix. doi: 10.1016/j.mric.2010.08.014.
Abstract
Iron overload is the histologic hallmark of hereditary hemochromatosis and transfusional hemosiderosis but also may occur in chronic hepatopathies. This article provides an overview of iron deposition and diseases where liver iron overload is clinically relevant. Next, this article reviews why quantitative noninvasive biomarkers of liver iron would be beneficial. Finally, we describe current state-of-the-art methods for quantifying iron with MR imaging and review remaining challenges and unsolved problems.
摘要
铁过载是遗传性血色素沉着症和输血性含铁血黄素沉着症的组织学标志，但也可能发生于慢性肝病。本文概述了铁沉积以及肝铁过载具有临床相关性的疾病。接下来，本文回顾了为何肝铁定量无创生物标志物会有益处。最后，我们描述了利用磁共振成像定量铁的当前先进方法，并回顾了尚存的挑战和未解决的问题。
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