Goldfarb A, Grisaru D, Gimmon Z, Okon E, Lebensart P, Rachmilewitz E A
Department of Hematology, Hadassah University Hospital, Jerusalem, Israel.
Acta Haematol. 1990;83(3):120-2. doi: 10.1159/000205186.
The records of 48 patients with homozygous beta-thalassemia were reviewed for evidence of cholelithiasis by abdominal ultrasonography or plain abdominal X-ray. The presence of cholelithiasis was reported in 25 patients (52%). The incidence increased with age to 83% in patients over 31 years of age. Gallstones were more frequent among patients with beta-thalassemia intermedia and with less blood transfusion requirements. Eleven patients with cholelithiasis (44%) became symptomatic. Eight received operations on an elective or semielective basis. Another patient had incidental cholecystectomy during splenectomy. The preoperative evaluation included abdominal ultrasonography, nucleotide biliary scan and evaluation of the cardiopulmonary status. Due to the longer survival of patients with homozygous beta-thalassemia, the problem of cholelithiasis is becoming more frequent.
回顾了48例纯合子β地中海贫血患者的记录，通过腹部超声或腹部平片检查胆石症证据。25例患者（52%）报告有胆石症。发病率随年龄增长，31岁以上患者中发病率增至83%。中间型β地中海贫血且输血需求较少的患者胆石症更为常见。11例胆石症患者（44%）出现症状。8例接受了择期或半择期手术。另一例患者在脾切除术时意外进行了胆囊切除术。术前评估包括腹部超声、核素胆道扫描和心肺状态评估。由于纯合子β地中海贫血患者生存期延长，胆石症问题正变得更加常见。
