Université de Montréal, Montréal, Canada.
Brain Cogn. 2011 Mar;75(2):111-8. doi: 10.1016/j.bandc.2010.10.011. Epub 2010 Nov 20.
The primary goal of this study was to evaluate the false recognition phenomenon in persons with frontotemporal dementia (FTD) and those with Lewy-body disease (LBD). Patients with LBD (n=10) or FTD (n=15) and their corresponding controls (n=30) were subjected to the Deese-Roediger-McDermott (DRM) paradigm to induce false recognition. Patients were first presented with items semantically related to a nonpresented critical target. The critical target was later included in a word list shown to patients to assess level of recognition. Both groups of patients showed a reduced level of false recognition of the critical target when controlling for their overall level of false alarms. This reduction was greater in persons with LBD than in those with FTD. Correlational analyses of performance on neuropsychological tests and the DRM variables indicated that the reduced DRM effect was associated with inhibition deficits in patients with LBD and with inhibition deficits and verbal memory in those with FTD. Our results support current models suggesting that these cognitive components contribute to the false recognition effect.
本研究的主要目的是评估额颞叶痴呆（FTD）和路易体病（LBD）患者的错误识别现象。将 LBD 患者（n=10）或 FTD 患者（n=15）及其相应的对照组（n=30）进行 Deese-Roediger-McDermott（DRM）范式以诱导错误识别。首先向患者呈现与未呈现的关键目标语义相关的项目。稍后将关键目标包含在向患者显示的单词列表中，以评估识别水平。在控制整体错误警报水平的情况下，两组患者对关键目标的错误识别水平均降低。在 LBD 患者中，这种降低的程度大于 FTD 患者。对神经心理学测试和 DRM 变量的表现进行的相关分析表明，DRM 效应的降低与 LBD 患者的抑制缺陷以及 FTD 患者的抑制缺陷和言语记忆有关。我们的结果支持当前的模型，这些模型表明这些认知成分有助于错误识别效应。
