Kim Chi Kyung, Lee Seung-Hoon, Kim Beom Joon, Ryu Wi-Sun, Choi Seung Ho, Oh Byung-Hee, Yoon Byung-Woo
Department of Neurology, Seoul National University Hospital, Seoul, Republic of Korea.
Clin Neurol Neurosurg. 2011 Apr;113(3):177-80. doi: 10.1016/j.clineuro.2010.10.013. Epub 2010 Nov 20.
Cerebral white matter lesions (WMLs) are radiologic markers of small vessel disease in brain, and inflammatory processes were related to WMLs. We propose to determine if elevated leukocyte count was associated with a higher risk of WMLs.
1586 asymptomatic subjects who visited our hospital for a routine health check-up were enrolled. Leukocyte counts were measured and the presence of moderate to severe WMLs was determined by brain MRI.
Thirty (1.9%) had moderate to severe WMLs, and a significant greater proportion (4.1%) of subjects in the highest leukocyte count quartile had moderate to severe WMLs. After adjusting by C-reactive protein, aspirin use and cardiovascular risk factors, the highest quartile of leukocyte count (≥6.7×10⁹/L) was significantly associated with moderate to severe WMLs compared with the lowest quartile [adjusted odds ratio, 4.03; 95% confidence interval, 1.05-15.5].
The authors report for the first time that an elevated leukocyte count is independently associated with moderate to severe WMLs.
脑白质病变（WMLs）是脑小血管疾病的影像学标志物，且炎症过程与WMLs相关。我们旨在确定白细胞计数升高是否与WMLs风险增加有关。
纳入1586名因常规健康检查来我院就诊的无症状受试者。测量白细胞计数，并通过脑部MRI确定中度至重度WMLs的存在情况。
30名（1.9%）受试者存在中度至重度WMLs，白细胞计数最高四分位数组中的受试者出现中度至重度WMLs的比例显著更高（4.1%）。在调整C反应蛋白、阿司匹林使用情况和心血管危险因素后，与最低四分位数相比，白细胞计数最高四分位数（≥⁹/L）与中度至重度WMLs显著相关[调整后的比值比为4.03；95%置信区间为1.05 - 15.5]。
作者首次报告白细胞计数升高与中度至重度WMLs独立相关。
