Carter A S, Bell G D, Coady T, Lee J, Morden A
Department of Anaesthesia, Ipswich Hospital, Suffolk, UK.
Acta Anaesthesiol Scand Suppl. 1990;92:59-64; discussion 78. doi: 10.1111/j.1399-6576.1990.tb03186.x.
Intravenous midazolam was given to 17 patients coming to upper G.I. endoscopy. All patients had an ear oximeter and calibrated induction plethysmograph attached to record oxygen saturation and minute volume continuously. Midazolam induced significant depression of respiration. Following removal of the endoscope, a new base line was obtained before giving intravenous flumazenil in an attempt to reverse the sedative and ventilatory effects of midazolam. When 0.5 mg of flumazenil was given over 20 s, followed by 0.1 mg every minute, up to a total of 1.0 mg, all patients were apparently awake in under 2 min. Although the flumazenil had clearly reversed the sedative effects of midazolam, the ventilatory effects were largely uninfluenced. The implications are discussed.
对17例接受上消化道内镜检查的患者静脉注射咪达唑仑。所有患者均佩戴耳式血氧计和校准后的诱导体积描记器，以持续记录血氧饱和度和每分通气量。咪达唑仑引起了显著的呼吸抑制。在内镜取出后，在静脉注射氟马西尼以试图逆转咪达唑仑的镇静和通气作用之前，获得了一个新的基线值。当在20秒内给予0.5毫克氟马西尼，随后每分钟给予0.1毫克，总量达1.0毫克时，所有患者在2分钟内明显清醒。尽管氟马西尼明显逆转了咪达唑仑的镇静作用，但通气作用基本未受影响。对其影响进行了讨论。
